J Fasipe Olumuyiwa1, A Akinbodewa Akinwumi2, O Adejumo Ademola2, B Akawa Oluwole1, E Okaka Ibiene3. 1. Department of Pharmacology and Therapeutics, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria. 2. Department of Internal Medicine, Kidney Care Centre, University of Medical Sciences, Ondo, Ondo State, Nigeria. 3. Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria.
Abstract
BACKGROUND: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. OBJECTIVES: This study determined the prevalence and pattern of potential DDIs among CKD patients attending Kidney Care Centre, in Ondo City, Nigeria. METHODOLOGY: It was an 18-month retrospective study that involved the reviewed CKD patients' records. The Lexi-Interact database was used to evaluate patients' medications for potential DDIs. RESULTS: One hundred and twenty-three (123) CKD patients, made up of 82 (66.67%) males and 41 (33.33%) females were studied. The mean age of the CKD patients was 53.81 ± 16.03 years. The most common comorbid conditions were hypertension in 103 (83.74%) and diabetes mellitus in 39 (31.71%). A total of 1237 prescriptions were made and the mean number of prescribed medications per patient was 10.06 ± 3.97. A total number of 1851 potential DDIs were observed among 118 patients. The prevalence of potential DDIs was 95.9% while the mean DDIs per prescription was 1.27. Among the potential DDIs observed, the severity was mild in 639 (34.5%), moderate in 1160 (62.7%), major in 51 (2.8%) and only 1 (0.1%) was of avoid drug combination. The most frequent DDI was between calcium carbonate and oral ferrous sulphate. CONCLUSION: The prevalence of potential DDIs is high among CKD patients. About 63% of these interactions have moderate severity. Clinicians and pharmacists should utilise available DDI software to avoid harmful DDIs in CKD patients.
BACKGROUND: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. OBJECTIVES: This study determined the prevalence and pattern of potential DDIs among CKDpatients attending Kidney Care Centre, in Ondo City, Nigeria. METHODOLOGY: It was an 18-month retrospective study that involved the reviewed CKDpatients' records. The Lexi-Interact database was used to evaluate patients' medications for potential DDIs. RESULTS: One hundred and twenty-three (123) CKDpatients, made up of 82 (66.67%) males and 41 (33.33%) females were studied. The mean age of the CKDpatients was 53.81 ± 16.03 years. The most common comorbid conditions were hypertension in 103 (83.74%) and diabetes mellitus in 39 (31.71%). A total of 1237 prescriptions were made and the mean number of prescribed medications per patient was 10.06 ± 3.97. A total number of 1851 potential DDIs were observed among 118 patients. The prevalence of potential DDIs was 95.9% while the mean DDIs per prescription was 1.27. Among the potential DDIs observed, the severity was mild in 639 (34.5%), moderate in 1160 (62.7%), major in 51 (2.8%) and only 1 (0.1%) was of avoid drug combination. The most frequent DDI was between calcium carbonate and oral ferrous sulphate. CONCLUSION: The prevalence of potential DDIs is high among CKDpatients. About 63% of these interactions have moderate severity. Clinicians and pharmacists should utilise available DDI software to avoid harmful DDIs in CKDpatients.
Authors: Dejan Z Aleksic; Slobodan M Jankovic; Milos N Mlosavljevic; Gordana L Toncev; Svetlana D Miletic Drakulic; Srdjan M Stefanovic Journal: Open Med (Wars) Date: 2019-11-07
Authors: Yemi R Raji; Samuel O Ajayi; Abiodun M Adeoye; Olukemi Amodu; Bamidele O Tayo; Babatunde L Salako Journal: Afr Health Sci Date: 2022-03 Impact factor: 1.108