Henrietta Tsosie1, James Thomas1, John Strong2, Antonios Zavaliangos3. 1. Materials Science and Engineering Department, Drexel University, 3141 Chestnut St. LeBow 344, Philadelphia, Pennsylvania, 19104, USA. 2. Global Pharmaceutical Sciences, AbbVie Inc., North Chicago, Illinois, 60064, USA. 3. Materials Science and Engineering Department, Drexel University, 3141 Chestnut St. LeBow 344, Philadelphia, Pennsylvania, 19104, USA. azavalia@coe.drexel.edu.
Abstract
PURPOSE: To obtain quantitative information and mechanistic insight into the problem of sticking of acetylsalicylic acid tablets on a metallic punch. METHODS: Low voltage scanning electron microscopy was used to observe punch area coverage and morphology of adhered powder on a flat punch used for a limited number of compactions. RESULTS: Material accumulation in terms of area coverage of the punch per compaction cycle was determined at two pressures over five compactions. The distribution of the adhered material on the punch was non-uniform with more material left on the center of the punch. The sizes of the adhered particles range from 1 to 100 μm, with 50% of the punch surface coverage from particles of an equivalent diameter > 30 μm. Three types of adhered particles were identified after the first compaction: (a) fragments of initial particles with very high aspect ratio, (b) nearly equiaxed fragments with multiple cracks, (c) heavily deformed islands of low profile. Some preliminary ideas that explain these observations are presented and discussed. CONCLUSIONS: The ability of SEM to provide quantitative information on sticking from few compactions presents an interesting possibility for a material sparing technique that provides insight on the propensity of sticking.
PURPOSE: To obtain quantitative information and mechanistic insight into the problem of sticking of acetylsalicylic acid tablets on a metallic punch. METHODS: Low voltage scanning electron microscopy was used to observe punch area coverage and morphology of adhered powder on a flat punch used for a limited number of compactions. RESULTS: Material accumulation in terms of area coverage of the punch per compaction cycle was determined at two pressures over five compactions. The distribution of the adhered material on the punch was non-uniform with more material left on the center of the punch. The sizes of the adhered particles range from 1 to 100 μm, with 50% of the punch surface coverage from particles of an equivalent diameter > 30 μm. Three types of adhered particles were identified after the first compaction: (a) fragments of initial particles with very high aspect ratio, (b) nearly equiaxed fragments with multiple cracks, (c) heavily deformed islands of low profile. Some preliminary ideas that explain these observations are presented and discussed. CONCLUSIONS: The ability of SEM to provide quantitative information on sticking from few compactions presents an interesting possibility for a material sparing technique that provides insight on the propensity of sticking.
Entities:
Keywords:
acetylsalicylic acid; scanning electron microscopy; sticking
Authors: Matthew Roberts; James L Ford; Graeme S MacLeod; John T Fell; George W Smith; Philip H Rowe Journal: J Pharm Pharmacol Date: 2003-09 Impact factor: 3.765
Authors: Matthew Roberts; James L Ford; Graeme S MacLeod; John T Fell; George W Smith; Philip H Rowe; A Mark Dyas Journal: J Pharm Pharmacol Date: 2004-07 Impact factor: 3.765