| Literature DB >> 2876101 |
A P Welbourn, C B Chapleo, A C Lane, P L Myers, A G Roach, C F Smith, M R Stillings, I F Tulloch.
Abstract
The resolution of three 2-substituted derivatives of idazoxan is described. The enantiomers show large separations in activity in a variety of in vitro and in vivo tests, and the active isomers are all potent and selective antagonists at the alpha 2-adrenoreceptor. The significance of these results in relation to those published on the enantiomers of idazoxan and to those on optically active alpha 2-adrenoreceptor agonists is discussed.Entities:
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Year: 1986 PMID： 2876101 DOI： 10.1021/jm00160a033
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446