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Literature DB >> 28760904

Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.

Kageto Yamada^1,2, Ryoichi Saito³, Saori Muto², Machiko Kashiwa², Yoshiko Tamamori², Shingo Fujisaki⁴.

Abstract

Moraxella catarrhalis causes respiratory infections. In this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. Strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets gyr and par were sequenced. Six novel mutations in GyrA (D84Y, T594dup, and A722dup), GyrB (E479K and D439N), and ParE (Q395R) involved in M. catarrhalis resistance to fluoroquinolones were revealed.

Entities: Chemical Disease Mutation Species

Keywords: Moraxella catarrhalis; fluoroquinolone; gyr; par; quinolone resistance-determining region

Mesh：

Substances：

Year: 2017 PMID： 28760904 PMCID： PMC5610493 DOI： 10.1128/AAC.01336-17

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates.

Authors: Franz-Josef Schmitz; Andreas Beeck; Mirella Perdikouli; Mechthild Boos; Susanne Mayer; Sybille Scheuring; Karl Köhrer; Jan Verhoef; Ad C Fluit
Journal: J Clin Microbiol Date: 2002-04 Impact factor: 5.948

2. Molecular analysis of low-level fluoroquinolone resistance in clinical isolates of Moraxella catarrhalis.

Authors: Kageto Yamada; Ryoichi Saito
Journal: J Med Microbiol Date: 2014-05-21 Impact factor: 2.472

Review 3. Mechanisms of resistance to quinolones.

Authors: George A Jacoby
Journal: Clin Infect Dis Date: 2005-07-15 Impact factor: 9.079

4. Genetic analysis of a pediatric clinical isolate of Moraxella catarrhalis with resistance to macrolides and quinolones.

Authors: Satoshi Iwata; Yoshitake Sato; Yoshikiyo Toyonaga; Hideaki Hanaki; Keisuke Sunakawa
Journal: J Infect Chemother Date: 2014-11-14 Impact factor: 2.211

5. bro {beta}-lactamase and antibiotic resistances in a global cross-sectional study of Moraxella catarrhalis from children and adults.

Authors: Mushtaq A Khan; John Blackman Northwood; Foster Levy; Suzanne J C Verhaegh; David J Farrell; Alex Van Belkum; John P Hays
Journal: J Antimicrob Chemother Date: 2010-01 Impact factor: 5.790

6. Antimicrobial susceptibility and mechanisms of high-level macrolide resistance in clinical isolates of Moraxella nonliquefaciens.

Authors: Shotaro Nonaka; Kosuke Matsuzaki; Tomoya Kazama; Hiroyuki Nishiyama; Yoko Ida; Saho Koyano; Kazunari Sonobe; Noboru Okamura; Ryoichi Saito
Journal: J Med Microbiol Date: 2013-11-06 Impact factor: 2.472

Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.

1. Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates.

2. Molecular analysis of low-level fluoroquinolone resistance in clinical isolates of Moraxella catarrhalis.

Review 3. Mechanisms of resistance to quinolones.

4. Genetic analysis of a pediatric clinical isolate of Moraxella catarrhalis with resistance to macrolides and quinolones.

5. bro {beta}-lactamase and antibiotic resistances in a global cross-sectional study of Moraxella catarrhalis from children and adults.

6. Antimicrobial susceptibility and mechanisms of high-level macrolide resistance in clinical isolates of Moraxella nonliquefaciens.

7. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.

8. Fluoroquinolone resistance in Neisseria meningitidis in Spain.

9. Analysis of quinolone resistance mechanisms in Neisseria gonorrhoeae isolates in vitro.

10. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus.

1. Soft sweep development of resistance in Escherichia coli under fluoroquinolone stress.