Literature DB >> 2876085

Laxatives and the production of autacoids by rat colon.

F Capasso, N Mascolo, G Autore, V Romano.   

Abstract

The effects of some laxatives were examined on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material (PG-LM) by rat intestine in-vitro. Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-HT and PG-LM. Indomethacin or hydrocortisone reduced the increase of PG-LM formation. The data support the idea that the laxative effects of these intestinal secretagogues are due to increased intestinal production of PG-LM, histamine and 5-HT.

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Year:  1986        PMID： 2876085     DOI： 10.1111/j.2042-7158.1986.tb03097.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  13 in total

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Authors:  G Staumont; J Fioramonti; J Frexinos; L Bueno
Journal:  Gut       Date:  1988-09       Impact factor: 23.059

2.  Constipation and risk of death and cardiovascular events.

Authors:  Keiichi Sumida; Miklos Z Molnar; Praveen K Potukuchi; Fridtjof Thomas; Jun Ling Lu; Kunihiro Yamagata; Kamyar Kalantar-Zadeh; Csaba P Kovesdy
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3.  Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats.

Authors:  Souleymane Méité; Calixte Bahi; Dodéhé Yéo; Jacques Y Datté; Joseph A Djaman; David J N'guessan
Journal:  BMC Complement Altern Med       Date:  2010-02-16       Impact factor: 3.659

4.  Constipation and Incident CKD.

Authors:  Keiichi Sumida; Miklos Z Molnar; Praveen K Potukuchi; Fridtjof Thomas; Jun Ling Lu; Kunihiro Matsushita; Kunihiro Yamagata; Kamyar Kalantar-Zadeh; Csaba P Kovesdy
Journal:  J Am Soc Nephrol       Date:  2016-11-10       Impact factor: 10.121

5.  Prostaglandin E2 and reactive oxygen metabolite damage in the cecum in a pony model of acute colitis.

Authors:  Rebecca S McConnico; Robert A Argenzio; Malcolm C Roberts
Journal:  Can J Vet Res       Date:  2002-01       Impact factor: 1.310

6.  Anti-nociceptive and anti-inflammatory effects of a Nigerian polyherbal tonic tea (PHT) extract in rodents.

Authors:  Agbaje Esther Oluwatoyin; Adeneye Adejuwon Adewale; Adeleke Tijani Isaac
Journal:  Afr J Tradit Complement Altern Med       Date:  2008-04-10

7.  Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat.

Authors:  N Mascolo; A A Izzo; F Barbato; F Capasso
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

8.  Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat.

Authors:  A Pinto; A Calignano; N Mascolo; G Autore; F Capasso
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

9.  Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester.

Authors:  F Capasso; N Mascolo; A A Izzo; T S Gaginella
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

Review 10.  A review on phyto-pharmacological potentials of Euphorbia thymifolia L.

Authors:  Prashant Y Mali; Shital S Panchal
Journal:  Anc Sci Life       Date:  2013-01
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