| Literature DB >> 2876084 |
M Szikszay, F R Snyder, E D London.
Abstract
The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer-344 rats. Morphine (4 mg kg-1) produced hypercapnia, hypoxia and slight acidosis, as compared with control values. Diltiazem (10 mg kg-1) alone did not affect these parameters; however, it significantly delayed the onset of the aforementioned effects of morphine.Entities:
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Year: 1986 PMID： 2876084 DOI： 10.1111/j.2042-7158.1986.tb03096.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765