| Literature DB >> 2876070 |
J Ferreira, R Brasseur, P Chatelain, J M Ruysschaert.
Abstract
Surface pressure measurements demonstrate that, over a wide range of pH, amiodarone forms a stable monolayer at the air-water interface. The area found to be occupied by an amiodarone molecule was compared with a theoretical prediction based on a conformational analysis, making it possible to assemble amphiphilic molecules. The intrinsic ionization constant of amiodarone in an aqueous environment pKi = 8.7 +/- 0.5 was evaluated from surface potential measurements.Entities:
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Year: 1986 PMID： 2876070 DOI： 10.1111/j.2042-7158.1986.tb03081.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765