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Literature DB >> 28760387

The role of Th17 cells in auto-inflammatory neurological disorders.

Foozhan Tahmasebinia¹, Arash Pourgholaminejad².

Abstract

The role of T helper 17 (Th17) cells in auto-inflammatory neurological disorders such as Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and schizophrenia has not been clarified completely. Th17-derived pro-inflammatory cytokines including IL-17, IL-21, IL-22, IL-23, GM-CSF, and IFN-γ have a critical role in the pathogenesis of these disorders. In this review, we demonstrate the role of Th17 cells and their related cytokines in the immunopathology of above-mentioned disorders to get a better understanding of neuroinflammatory mechanisms mediated by Th17 cells associated with events leading to neurodegeneration.

Entities: Disease Gene

Keywords: Alzheimer's disease; Multiple sclerosis; Neurodegenerative disorders; Neuroinflammation; Parkinson's disease; Schizophrenia; Th17 cells

Mesh：

Year: 2017 PMID： 28760387 DOI： 10.1016/j.pnpbp.2017.07.023

Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067

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