Brinda K Rana1, Matthew S Panizzon1, Carol E Franz1, Kelly M Spoon2, Kristen C Jacobson3, Hong Xian4, Sonia Ancoli-Israel1, Michael Lyons5, William S Kremen1. 1. 1Department of Psychiatry,University of California,San Diego,La Jolla,California. 2. 2Center for Behavioral Genetics of Aging,University of California, San Diego,La Jolla,California. 3. 5Department of Psychiatry & Behavioral Neuroscience,University of Chicago,Chicago,Illinois. 4. 6Department of Biostatistcs,St. Louis University School of Public Health,St. Louis,MO. 5. 9Department of Psychological and Brain Sciences,Boston University,Boston,Massachusetts.
Abstract
OBJECTIVES: Sleep quality affects memory and executive function in older adults, but little is known about its effects in midlife. If it affects cognition in midlife, it may be a modifiable factor for later-life functioning. METHODS: We examined the association between sleep quality and cognition in 1220 middle-aged male twins (age 51-60 years) from the Vietnam Era Twin Study of Aging. We interviewed participants with the Pittsburgh Sleep Quality Index and tested them for episodic memory as well as executive functions of inhibitory and interference control, updating in working memory, and set shifting. Interference control was assessed during episodic memory, inhibitory control during working memory, and non-memory conditions and set shifting during working memory and non-memory conditions. RESULTS: After adjusting for covariates and correcting for multiple comparisons, sleep quality was positively associated with updating in working memory, set shifting in the context of working memory, and better visual-spatial (but not verbal) episodic memory, and at trend level, with interference control in the context of episodic memory. CONCLUSIONS: Sleep quality was associated with visual-spatial recall and possible resistance to proactive/retroactive interference. It was also associated with updating in working memory and with set shifting, but only when working memory demands were relatively high. Thus, effects of sleep quality on midlife cognition appear to be at the intersection of executive function and memory processes. Subtle deficits in these age-susceptible cognitive functions may indicate increased risk for decline in cognitive abilities later in life that might be reduced by improved midlife sleep quality. (JINS, 2018, 24, 67-76).
OBJECTIVES: Sleep quality affects memory and executive function in older adults, but little is known about its effects in midlife. If it affects cognition in midlife, it may be a modifiable factor for later-life functioning. METHODS: We examined the association between sleep quality and cognition in 1220 middle-aged male twins (age 51-60 years) from the Vietnam Era Twin Study of Aging. We interviewed participants with the Pittsburgh Sleep Quality Index and tested them for episodic memory as well as executive functions of inhibitory and interference control, updating in working memory, and set shifting. Interference control was assessed during episodic memory, inhibitory control during working memory, and non-memory conditions and set shifting during working memory and non-memory conditions. RESULTS: After adjusting for covariates and correcting for multiple comparisons, sleep quality was positively associated with updating in working memory, set shifting in the context of working memory, and better visual-spatial (but not verbal) episodic memory, and at trend level, with interference control in the context of episodic memory. CONCLUSIONS: Sleep quality was associated with visual-spatial recall and possible resistance to proactive/retroactive interference. It was also associated with updating in working memory and with set shifting, but only when working memory demands were relatively high. Thus, effects of sleep quality on midlife cognition appear to be at the intersection of executive function and memory processes. Subtle deficits in these age-susceptible cognitive functions may indicate increased risk for decline in cognitive abilities later in life that might be reduced by improved midlife sleep quality. (JINS, 2018, 24, 67-76).
Entities:
Keywords:
Cognition; Executive function; Memory; PSQI; Resistance to interference; VETSA
Authors: Adam P Spira; Sherry A Beaudreau; Katie L Stone; Eric J Kezirian; Li-Yung Lui; Susan Redline; Sonia Ancoli-Israel; Kristine Ensrud; Anita Stewart Journal: J Gerontol A Biol Sci Med Sci Date: 2011-09-20 Impact factor: 6.053
Authors: William S Kremen; Heather Thompson-Brenner; Yat-Ming J Leung; Michael D Grant; Carol E Franz; Seth A Eisen; Kristen C Jacobson; Corwin Boake; Michael J Lyons Journal: Twin Res Hum Genet Date: 2006-12 Impact factor: 1.587
Authors: Jordy van Enkhuizen; Dean Acheson; Victoria Risbrough; Sean Drummond; Mark A Geyer; Jared W Young Journal: Behav Brain Res Date: 2013-12-12 Impact factor: 3.332
Authors: Terri Blackwell; Kristine Yaffe; Sonia Ancoli-Israel; Susan Redline; Kristine E Ensrud; Marcia L Stefanick; Alison Laffan; Katie L Stone Journal: J Am Geriatr Soc Date: 2011-11-07 Impact factor: 5.562
Authors: Henry C Driscoll; Linda Serody; Susan Patrick; Jennifer Maurer; Salem Bensasi; Patricia R Houck; Sati Mazumdar; Eric A Nofzinger; Bethany Bell; Robert D Nebes; Mark D Miller; Charles F Reynolds Journal: Am J Geriatr Psychiatry Date: 2007-12-10 Impact factor: 4.105
Authors: Robert D Nebes; Daniel J Buysse; Edythe M Halligan; Patricia R Houck; Timothy H Monk Journal: J Gerontol B Psychol Sci Soc Sci Date: 2009-02-09 Impact factor: 4.077
Authors: Laura M Campbell; Maulika Kohli; Ellen E Lee; Christopher N Kaufmann; Michael Higgins; Jeremy D Delgadillo; Robert K Heaton; Mariana Cherner; Ronald J Ellis; David J Moore; Raeanne C Moore Journal: Clin Neuropsychol Date: 2020-09-30 Impact factor: 4.373
Authors: Javier Labad; Neus Salvat-Pujol; Antonio Armario; Ángel Cabezas; Aida de Arriba-Arnau; Roser Nadal; Lourdes Martorell; Mikel Urretavizcaya; José Antonio Monreal; José Manuel Crespo; Elisabet Vilella; Diego José Palao; José Manuel Menchón; Virginia Soria Journal: Int J Environ Res Public Health Date: 2020-10-19 Impact factor: 3.390