Literature DB >> 2875911

Immunohistochemical colocalization of GABA and insulin in beta-cells of rat islet.

D J Garry, R L Sorenson, R P Elde, B E Maley, A Madsen.   

Abstract

gamma-Aminobutyric acid (GABA) is found in high concentrations in the pancreatic islet. In addition, enzymes regulating the level of GABA (L-glutamate decarboxylase and GABA-alpha-ketoglutarate transaminase) have been immunohistochemically localized in the medullary cells of the islet. In this study, an immunofluorescence and elution/restaining protocol is used to determine the distribution of GABA and either insulin, glucagon, or somatostatin in a tissue section. GABA was not detected within the islet alpha- or delta-cells but was determined to be localized within the insulin-containing beta-cells.

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Year:  1986        PMID： 2875911     DOI： 10.2337/diab.35.10.1090

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  13 in total

1.  A Historical Perspective on the Identification of Cell Types in Pancreatic Islets of Langerhans by Staining and Histochemical Techniques.

Authors:  Denis G Baskin
Journal:  J Histochem Cytochem       Date:  2015-08       Impact factor: 2.479

Review 2.  Colocalization of amino acid signal molecules in neurons and endocrine cells.

Authors:  S Davanger
Journal:  Anat Embryol (Berl)       Date:  1996-07

Review 3.  Paracrine interactions within islets of Langerhans.

Authors:  Duk-Su Koh; Jung-Hwa Cho; Liangyi Chen
Journal:  J Mol Neurosci       Date:  2012-04-13       Impact factor: 3.444

Review 4.  A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex.

Authors:  Johan H Koeslag; Peter T Saunders; Elmarie Terblanche
Journal:  J Physiol       Date:  2003-04-25       Impact factor: 5.182

5.  Ultrastructural localization of gamma amino butyric acid immunoreactivity in B cells of the rat pancreas.

Authors:  D J Garry; R L Sorenson; H D Coulter
Journal:  Diabetologia       Date:  1987-02       Impact factor: 10.122

6.  Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies.

Authors:  W Richter; T H Eiermann; J Endl; J Seissler; S Wolfahrt; M Brandt; H Jungfer; W A Scherbaum
Journal:  Diabetologia       Date:  1993-08       Impact factor: 10.122

7.  Decreased GABAA receptor function in the brain stem during pancreatic regeneration in rats.

Authors:  S Balarama Kaimal; G Gireesh; C S Paulose
Journal:  Neurochem Res       Date:  2007-08-14       Impact factor: 3.996

8.  Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme.

Authors:  M R Christie; T J Brown; D Cassidy
Journal:  Diabetologia       Date:  1992-04       Impact factor: 10.122

9.  Autoradiographic studies of the gamma-aminobutyric acid (GABA) system in the rat pancreas.

Authors:  S R Vicent; J C Brown
Journal:  Histochemistry       Date:  1988

10.  Gamma-aminobutyric acid (GABA) immunoreactivity in the mouse adrenal gland.

Authors:  Y Oomori; H Iuchi; K Nakaya; H Tanaka; K Ishikawa; Y Satoh; K Ono
Journal:  Histochemistry       Date:  1993-09
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