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Literature DB >> 28758251

Insulin action in the brain: Roles in energy and glucose homeostasis.

Abstract

A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates diverse aspects of energy balance and peripheral glucose homeostasis. This review discusses where and how insulin interacts within the brain and evaluates the physiological and pathophysiological consequences of central insulin signalling in metabolism, obesity and type 2 diabetes.

Entities: Disease Gene Species

Keywords: AgRP; POMC; energy homeostasis; glucose homeostasis; hypothalamus; insulin

Mesh：

Substances：
Insulin
Glucose

Year: 2017 PMID： 28758251 DOI： 10.1111/jne.12513

Source DB: PubMed Journal: J Neuroendocrinol ISSN： 0953-8194 Impact factor: 3.627

Keyword Cloud
Cited

24 in total

1. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism.

Authors: Mariana Rosolen Tavares; Simone Ferreira Lemes; Thais de Fante; Cristina Saenz de Miera; Isadora Carolina Betim Pavan; Rosangela Maria Neves Bezerra; Patricia Oliveira Prada; Marcio Alberto Torsoni; Carol Fuzeti Elias; Fernando Moreira Simabuco
Journal: J Endocrinol Date: 2020-01-01 Impact factor: 4.286

Review 2. Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus.

Authors: Adilson Guilherme; Felipe Henriques; Alexander H Bedard; Michael P Czech
Journal: Nat Rev Endocrinol Date: 2019-04 Impact factor: 43.330

Review 3. The melanocortin pathway and control of appetite-progress and therapeutic implications.

Authors: Giulia Baldini; Kevin D Phelan
Journal: J Endocrinol Date: 2019-04-01 Impact factor: 4.286

4. Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.

Authors: Fei Yan; Ju Liu; Mei-Xiang Chen; Ying Zhang; Sheng-Jiao Wei; Hai Jin; Jing Nie; Xiao-Long Fu; Jing-Shan Shi; Shao-Yu Zhou; Feng Jin
Journal: Neural Regen Res Date: 2023-01 Impact factor: 6.058

Insulin action in the brain: Roles in energy and glucose homeostasis.

1. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism.

Review 2. Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus.

Review 3. The melanocortin pathway and control of appetite-progress and therapeutic implications.

4. Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.

Review 5. Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment.

6. Membrane and nuclear initiated estrogenic regulation of homeostasis.

Review 7. Insulin action in the brain regulates both central and peripheral functions.

Review 8. Traumatic Brain Injury: At the Crossroads of Neuropathology and Common Metabolic Endocrinopathies.

Review 9. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.

10. Glucagon's Metabolic Action in Health and Disease.