Literature DB >> 28757624

Calls grow to tap the gold mine of human genetic knockouts.

Asher Mullard.   

Abstract

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Year:  2017        PMID： 28757624     DOI： 10.1038/nrd.2017.139

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  4 in total

1.  Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.

Authors:  Phuong A Nguyen; David A Born; Aimee M Deaton; Paul Nioi; Lucas D Ward
Journal:  Nat Commun       Date:  2019-04-05       Impact factor: 14.919

2.  Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers.

Authors:  B Grubinska; L Chen; M Alsaloum; N Rampal; D J Matson; C Yang; K Taborn; M Zhang; B Youngblood; D Liu; E Galbreath; S Allred; M Lepherd; R Ferrando; T J Kornecook; S G Lehto; S G Waxman; B D Moyer; S Dib-Hajj; J Gingras
Journal:  Mol Pain       Date:  2019 Jan-Dec       Impact factor: 3.395

Review 3.  Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

Authors:  Laura J Corbin; Vanessa Y Tan; David A Hughes; Kaitlin H Wade; Dirk S Paul; Katherine E Tansey; Frances Butcher; Frank Dudbridge; Joanna M Howson; Momodou W Jallow; Catherine John; Nathalie Kingston; Cecilia M Lindgren; Michael O'Donavan; Stephen O'Rahilly; Michael J Owen; Colin N A Palmer; Ewan R Pearson; Robert A Scott; David A van Heel; John Whittaker; Tim Frayling; Martin D Tobin; Louise V Wain; George Davey Smith; David M Evans; Fredrik Karpe; Mark I McCarthy; John Danesh; Paul W Franks; Nicholas J Timpson
Journal:  Nat Commun       Date:  2018-02-19       Impact factor: 14.919

4.  Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.

Authors:  Tracy L McGregor; Karen A Hunt; Elaine Yee; Dan Mason; Paul Nioi; Simina Ticau; Marissa Pelosi; Perry R Loken; Sarah Finer; Deborah A Lawlor; Eric B Fauman; Qin Qin Huang; Christopher J Griffiths; Daniel G MacArthur; Richard C Trembath; Devin Oglesbee; John C Lieske; David V Erbe; John Wright; David A van Heel
Journal:  Elife       Date:  2020-03-24       Impact factor: 8.140
  4 in total

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