Literature DB >> 28757603

The regulation of immune tolerance by FOXP3.

Ling Lu1, Joseph Barbi2, Fan Pan3.   

Abstract

The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of Treg cells, and FOXP3 is centrally involved in the establishment and maintenance of the Treg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.

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Year:  2017        PMID： 28757603      PMCID： PMC5793224          DOI： 10.1038/nri.2017.75

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  157 in total

1.  Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Authors:  Yukihiro Furusawa; Yuuki Obata; Shinji Fukuda; Takaho A Endo; Gaku Nakato; Daisuke Takahashi; Yumiko Nakanishi; Chikako Uetake; Keiko Kato; Tamotsu Kato; Masumi Takahashi; Noriko N Fukuda; Shinnosuke Murakami; Eiji Miyauchi; Shingo Hino; Koji Atarashi; Satoshi Onawa; Yumiko Fujimura; Trevor Lockett; Julie M Clarke; David L Topping; Masaru Tomita; Shohei Hori; Osamu Ohara; Tatsuya Morita; Haruhiko Koseki; Jun Kikuchi; Kenya Honda; Koji Hase; Hiroshi Ohno
Journal:  Nature       Date:  2013-11-13       Impact factor: 49.962

2.  The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Authors:  Ruoning Wang; Christopher P Dillon; Lewis Zhichang Shi; Sandra Milasta; Robert Carter; David Finkelstein; Laura L McCormick; Patrick Fitzgerald; Hongbo Chi; Joshua Munger; Douglas R Green
Journal:  Immunity       Date:  2011-12-23       Impact factor: 31.745

3.  Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

Authors:  Ye Zheng; Steven Z Josefowicz; Arnold Kas; Tin-Tin Chu; Marc A Gavin; Alexander Y Rudensky
Journal:  Nature       Date:  2007-01-21       Impact factor: 49.962

4.  Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.

Authors:  Xuefang Cao; Sheng F Cai; Todd A Fehniger; Jiling Song; Lynne I Collins; David R Piwnica-Worms; Timothy J Ley
Journal:  Immunity       Date:  2007-10-04       Impact factor: 31.745

5.  Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells.

Authors:  Fuping Zhang; Guangxun Meng; Warren Strober
Journal:  Nat Immunol       Date:  2008-10-12       Impact factor: 25.606

6.  FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

Authors:  Bin Li; Arabinda Samanta; Xiaomin Song; Kathryn T Iacono; Patrick Brennan; Talal A Chatila; Giovanna Roncador; Alison H Banham; James L Riley; Qiang Wang; Yuan Shen; Sandra J Saouaf; Mark I Greene
Journal:  Int Immunol       Date:  2007-06-22       Impact factor: 4.823

7.  Control of Foxp3 stability through modulation of TET activity.

Authors:  Xiaojing Yue; Sara Trifari; Tarmo Äijö; Ageliki Tsagaratou; William A Pastor; Jorge A Zepeda-Martínez; Chan-Wang J Lio; Xiang Li; Yun Huang; Pandurangan Vijayanand; Harri Lähdesmäki; Anjana Rao
Journal:  J Exp Med       Date:  2016-02-22       Impact factor: 14.307

8.  DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases.

Authors:  Varun Sasidharan Nair; Mi Hye Song; Myunggon Ko; Kwon Ik Oh
Journal:  Mol Cells       Date:  2016-12-13       Impact factor: 5.034

9.  CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.

Authors:  Hyoung-Pyo Kim; Warren J Leonard
Journal:  J Exp Med       Date:  2007-06-25       Impact factor: 14.307

10.  IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Authors:  Reiner K W Mailer; Anne-Laure Joly; Sang Liu; Szabolcs Elias; Jesper Tegner; John Andersson
Journal:  Sci Rep       Date:  2015-10-06       Impact factor: 4.379
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  169 in total

1.  Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice.

Authors:  Anusara Daenthanasanmak; Supinya Iamsawat; Paramita Chakraborty; Hung D Nguyen; David Bastian; Chen Liu; Shikhar Mehrotra; Xue-Zhong Yu
Journal:  Blood       Date:  2018-12-04       Impact factor: 22.113

2.  Hepatitis B Virus Core Particles Containing a Conserved Region of the G Protein Combined with Interleukin-35 Protected Mice against Respiratory Syncytial Virus Infection without Vaccine-Enhanced Immunopathology.

Authors:  Jie Yang; Chen Ma; Yu Zhao; Anjing Fan; Xiufen Zou; Zishu Pan
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

3.  FOXP3 immunoregulatory gene variants are independent predictors of human papillomavirus infection and cervical cancer precursor lesions.

Authors:  Fernando Cezar-Dos-Santos; Rodolfo Sanches Ferreira; Nádia Calvo Martins Okuyama; Kleber Paiva Trugilo; Michelle Mota Sena; Érica Romão Pereira; Ana Paula Lombardi Pereira; Maria Angelica Ehara Watanabe; Karen Brajão de Oliveira
Journal:  J Cancer Res Clin Oncol       Date:  2019-06-08       Impact factor: 4.553

Review 4.  Regulation of T cell differentiation and function by epigenetic modification enzymes.

Authors:  Huicheng Liu; Pingfei Li; Zhengping Wei; Cai Zhang; Minghui Xia; Qiuyang Du; Yufei Chen; Na Liu; Huabin Li; Xiang-Ping Yang
Journal:  Semin Immunopathol       Date:  2019-04-08       Impact factor: 9.623

Review 5.  Epigenetic regulation of T helper cells and intestinal pathogenicity.

Authors:  Yuya Hagihara; Yusuke Yoshimatsu; Yohei Mikami; Yoshiaki Takada; Shinta Mizuno; Takanori Kanai
Journal:  Semin Immunopathol       Date:  2019-03-19       Impact factor: 9.623

6.  Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

Authors:  Manuel A R Ferreira; Riddhima Mathur; Judith M Vonk; Agnieszka Szwajda; Ben Brumpton; Raquel Granell; Bronwyn K Brew; Vilhelmina Ullemar; Yi Lu; Yunxuan Jiang; Patrik K E Magnusson; Robert Karlsson; David A Hinds; Lavinia Paternoster; Gerard H Koppelman; Catarina Almqvist
Journal:  Am J Hum Genet       Date:  2019-03-28       Impact factor: 11.025

Review 7.  Immunologic Milieu of Mature T-Cell and NK-Cell Lymphomas-Implications for Therapy.

Authors:  Eric Tse; Yok-Lam Kwong
Journal:  Curr Hematol Malig Rep       Date:  2018-02       Impact factor: 3.952

8.  Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

Authors:  Susanta Mondal; Malabendu Jana; Sridevi Dasarathi; Avik Roy; Kalipada Pahan
Journal:  Sci Signal       Date:  2018-11-27       Impact factor: 8.192

Review 9.  Maternal and fetal T cells in term pregnancy and preterm labor.

Authors:  Derek Miller; Meyer Gershater; Rebecca Slutsky; Roberto Romero; Nardhy Gomez-Lopez
Journal:  Cell Mol Immunol       Date:  2020-05-28       Impact factor: 11.530

10.  A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Authors:  Frédéric Van Gool; Michelle L T Nguyen; Maxwell R Mumbach; Ansuman T Satpathy; Wendy L Rosenthal; Simone Giacometti; Duy T Le; Weihong Liu; Todd M Brusko; Mark S Anderson; Alexander Y Rudensky; Alexander Marson; Howard Y Chang; Jeffrey A Bluestone
Journal:  Immunity       Date:  2019-01-29       Impact factor: 31.745
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