Ayman Samman Tahhan1, Pratik B Sandesara1, Salim S Hayek1, Ayman Alkhoder1, Kaavya Chivukula1, Muhammad Hammadah1, Heval Mohamed-Kelli1, Wesley T O'Neal1, Matthew Topel1, Nima Ghasemzadeh1, Yi-An Ko2, Hiroshi Aida1, Mazen Gafeer1, Laurence Sperling1, Viola Vaccarino3, Yongliang Liang4, Dean P Jones4, Arshed A Quyyumi5. 1. Division of Cardiology, Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia. 2. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. 3. Division of Cardiology, Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. 4. Division of Pulmonary, Allergy and Critical Care Medicine, Clinical Biomarkers Laboratory, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. 5. Division of Cardiology, Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia. Electronic address: aquyyum@emory.edu.
Abstract
BACKGROUND: Oxidative stress (OS) may be a key mechanism underlying the development of atrial fibrillation (AF) in experimental studies, but data in humans remain limited. OBJECTIVE: Systemic OS can be estimated by measurements of circulating levels of the aminothiols including glutathione, cysteine, and their oxidized products. We tested the hypothesis that the redox potentials of glutathione (EhGSH) and cysteine will be associated with prevalent and incident AF. METHODS: Plasma levels of aminothiols were measured in 1439 patients undergoing coronary angiography, of whom 148 (10.3%) had a diagnosis of AF. After a median follow-up of 6.3 years, 104 of 917 patients (11.5%) developed incident AF. Multivariate logistic regression and Cox regression models were used to determine whether OS markers were independent predictors of prevalent and incident AF after adjustment for traditional risk factors, heart failure, coronary artery disease, and high-sensitivity C-reactive protein level. RESULTS: For each 10% increase in EhGSH, the odds of prevalent AF was 30% higher (odds ratio [OR] 1.3; 95% confidence interval [CI] 1.1-1.7; P = .02) and 90% higher (OR 1.9; 95% CI 1.3-2.7; P = .004) when the median was used as a cutoff. The EhGSH level above the median was more predictive of chronic AF (OR 4.0; 95% CI 1.3-12.9; P = .01) than of paroxysmal AF (OR 1.7; 95% CI 1.1-2.7; P = .03). Each 10% increase in EhGSH level was associated with a 40% increase in the risk of incident AF (hazard ratio 1.4; 95% CI 1.1-1.7; P = .01). CONCLUSION: Increased OS measured by the redox potentials of glutathione is associated with prevalent and incident AF. Therapies that modulate OS need to be investigated to treat and prevent AF.
BACKGROUND: Oxidative stress (OS) may be a key mechanism underlying the development of atrial fibrillation (AF) in experimental studies, but data in humans remain limited. OBJECTIVE: Systemic OS can be estimated by measurements of circulating levels of the aminothiols including glutathione, cysteine, and their oxidized products. We tested the hypothesis that the redox potentials of glutathione (EhGSH) and cysteine will be associated with prevalent and incident AF. METHODS: Plasma levels of aminothiols were measured in 1439 patients undergoing coronary angiography, of whom 148 (10.3%) had a diagnosis of AF. After a median follow-up of 6.3 years, 104 of 917 patients (11.5%) developed incident AF. Multivariate logistic regression and Cox regression models were used to determine whether OS markers were independent predictors of prevalent and incident AF after adjustment for traditional risk factors, heart failure, coronary artery disease, and high-sensitivity C-reactive protein level. RESULTS: For each 10% increase in EhGSH, the odds of prevalent AF was 30% higher (odds ratio [OR] 1.3; 95% confidence interval [CI] 1.1-1.7; P = .02) and 90% higher (OR 1.9; 95% CI 1.3-2.7; P = .004) when the median was used as a cutoff. The EhGSH level above the median was more predictive of chronic AF (OR 4.0; 95% CI 1.3-12.9; P = .01) than of paroxysmal AF (OR 1.7; 95% CI 1.1-2.7; P = .03). Each 10% increase in EhGSH level was associated with a 40% increase in the risk of incident AF (hazard ratio 1.4; 95% CI 1.1-1.7; P = .01). CONCLUSION: Increased OS measured by the redox potentials of glutathione is associated with prevalent and incident AF. Therapies that modulate OS need to be investigated to treat and prevent AF.
Authors: John F Keaney; Martin G Larson; Ramachandran S Vasan; Peter W F Wilson; Izabella Lipinska; Diane Corey; Joseph M Massaro; Patrice Sutherland; Joseph A Vita; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2003-01-30 Impact factor: 8.311
Authors: Jie Li; Joseph Solus; Qingxia Chen; Young Hee Rho; Ginger Milne; C Michael Stein; Dawood Darbar Journal: Heart Rhythm Date: 2009-12-24 Impact factor: 6.343
Authors: Young M Kim; Hassan Kattach; Chandi Ratnatunga; Ravi Pillai; Keith M Channon; Barbara Casadei Journal: J Am Coll Cardiol Date: 2008-01-01 Impact factor: 24.094
Authors: Priit Pauklin; Mihkel Zilmer; Jaan Eha; Kaspar Tootsi; Mart Kals; Priit Kampus Journal: Oxid Med Cell Longev Date: 2022-05-23 Impact factor: 7.310
Authors: Shin Yoo; Anna Pfenniger; Jacob Hoffman; Wenwei Zhang; Jason Ng; Amy Burrell; David A Johnson; Georg Gussak; Trent Waugh; Suzanne Bull; Brandon Benefield; Bradley P Knight; Rod Passman; J Andrew Wasserstrom; Gary L Aistrup; Rishi Arora Journal: Circulation Date: 2020-07-20 Impact factor: 39.918
Authors: Zachary J Rhinehart; Ellen Kinnee; Utibe R Essien; Melissa Saul; Emily Guhl; Jane E Clougherty; Jared W Magnani Journal: JAMA Netw Open Date: 2020-09-01