Lu Hao1, Xiang-Peng Zeng1, Lei Xin2, Dan Wang1, Jun Pan1, Ya-Wei Bi1, Jun-Tao Ji3, Ting-Ting Du1, Jin-Huan Lin1, Di Zhang1, Bo Ye4, Wen-Bin Zou1, Hui Chen2, Ting Xie5, Bai-Rong Li6, Zhao-Hong Zheng7, Teng Wang2, Hong-Lei Guo1, Zhuan Liao2, Zhao-Shen Li8, Liang-Hao Hu9. 1. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China. 2. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China. 3. Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China. 4. Department of surgery, Jinling Hospital, Nanjing, China. 5. Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, China. 6. Department of Gastroenterology, Air Force General Hospital, Beijing, China. 7. Department of Traditional Chinese Medicine, Jiangdu Hospital, Yangzhou, China. 8. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address: zhaoshen-li@hotmail.com. 9. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address: lianghao-hu@hotmail.com.
Abstract
BACKGROUND: Risk of pancreatic cancer may increase in chronic pancreatitis patients. AIMS: This study aimed to identify the incidence of and risk factors for pancreatic cancer in chronic pancreatitis patients. METHODS: Chronic pancreatitis patients admitted to our center from January 2000 to December 2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were calculated. The standardized incidence ratio was calculated based on the pancreatic cancer incidence in general population of China. Risk factors for pancreatic cancer were identified. RESULTS: In a total of 1656 patients, the median follow-up duration was 8.0 years. Pancreatic cancer was detected in 21 patients (1.3%). The expected number of cases of pancreatic cancer was 1.039, yielding a standardized incidence ratio of 20.22. The standardized incidence ratios for patients with a >60 pack-year smoking history were much higher (145.82). Two risk factors for pancreatic cancer were identified: age at the onset of chronic pancreatitis (hazard ratio, 1.05) and a >60 pack-year smoking history (hazard ratio, 11.83). CONCLUSION: The risk of pancreatic cancer is markedly increased in chronic pancreatitis patients compared with the general population, especially in patients with an older age at onset and a >60 pack-year smoking history. The high-risk populations were suggested to be followed up closely.
BACKGROUND: Risk of pancreatic cancer may increase in chronic pancreatitispatients. AIMS: This study aimed to identify the incidence of and risk factors for pancreatic cancer in chronic pancreatitispatients. METHODS:Chronic pancreatitispatients admitted to our center from January 2000 to December 2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were calculated. The standardized incidence ratio was calculated based on the pancreatic cancer incidence in general population of China. Risk factors for pancreatic cancer were identified. RESULTS: In a total of 1656 patients, the median follow-up duration was 8.0 years. Pancreatic cancer was detected in 21 patients (1.3%). The expected number of cases of pancreatic cancer was 1.039, yielding a standardized incidence ratio of 20.22. The standardized incidence ratios for patients with a >60 pack-year smoking history were much higher (145.82). Two risk factors for pancreatic cancer were identified: age at the onset of chronic pancreatitis (hazard ratio, 1.05) and a >60 pack-year smoking history (hazard ratio, 11.83). CONCLUSION: The risk of pancreatic cancer is markedly increased in chronic pancreatitispatients compared with the general population, especially in patients with an older age at onset and a >60 pack-year smoking history. The high-risk populations were suggested to be followed up closely.
Authors: Furqan A Bhullar; Mahya Faghih; Venkata S Akshintala; Ahmed I Ahmed; Katie Lobner; Elham Afghani; Anna E Phillips; Phil A Hart; Mitchell L Ramsey; Benjamin L Bick; Louise Kuhlmann; Asbjørn M Drewes; Dhiraj Yadav; Søren S Olesen; Vikesh K Singh Journal: Pancreatology Date: 2021-11-18 Impact factor: 3.996
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Authors: Lixia Wang; Srinivas Gaddam; Nan Wang; Yibin Xie; Zixin Deng; Zhengwei Zhou; Zhaoyang Fan; Tao Jiang; Anthony G Christodoulou; Fei Han; Simon K Lo; Ashley M Wachsman; Andrew Eugene Hendifar; Stephen J Pandol; Debiao Li Journal: Front Physiol Date: 2020-02-21 Impact factor: 4.566