Literature DB >> 28756498

Post-transplant erythrocytosis-related maculopathy: successful management of hyperviscosity with phlebotomy.

Sumeet Khanduja1, Brijesh Takkar2, Neha Khanduja3, Pradeep Venkatesh4.   

Abstract

PURPOSE: To report clinical features in a case of hyperviscosity retinopathy following post-renal transplant erythrocytosis (PTE) and its outcome after phlebotomy.
METHODS: Fundus fluorescein angiography and optical coherence tomography (OCT) were carried out for a 29-year-old renal allograft recipient who presented with acute unilateral visual loss. RESULT: There was mild retinal vascular dilation in both eyes with retinal hemorrhages and retinal opaqueness in left eye. Cystoid macular edema was noted on OCT. Microvascular leaks and micro-occlusions were seen all around the foveal avascular zone on fluorescein angiogram. Investigations revealed hemoglobin to be 16.8 g%, and a PTE was diagnosed. The patient underwent phlebotomy following which there was near complete resolution of macular edema with improvement in vision.
CONCLUSION: Hyperviscosity retinopathy can cause acute visual loss in cases of renal allograft recipients who develop PTE. Prompt management with phlebotomy can lead to reversal of macular edema in such cases.

Entities:  

Keywords:  Cystoid macular edema; Hyperviscosity retinopathy; Phlebotomy; Post-renal transplant erythrocytosis

Mesh:

Year:  2017        PMID: 28756498     DOI: 10.1007/s10792-017-0660-x

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  9 in total

1.  Ocular complications in renal allograft recipients.

Authors:  H R Jahadi-hosseini; B Rahmani; A Karbassi; M Mehrian; A R Medghalchi
Journal:  Transplant Proc       Date:  2003-02       Impact factor: 1.066

2.  Major ocular complications after organ transplantation.

Authors:  Paolo Lanzetta; Pietro Monaco
Journal:  Indian J Ophthalmol       Date:  2004-06       Impact factor: 1.848

3.  Ocular complications in renal transplant recipients.

Authors:  A E Oberman; S N Chatterjee
Journal:  West J Med       Date:  1975-09

4.  Bilateral macular infarction secondary to haemodialysis in a patient with chronic renal failure.

Authors:  Sinha Subijay; Gogia Varun; Gupta Shikha; Venkatesh Pradeep; Khanduja Sumeet
Journal:  Clin Exp Ophthalmol       Date:  2011-09-02       Impact factor: 4.207

5.  Immunogammopathy maculopathy associated with Waldenström macroglobulinemia is refractory to conventional interventions for macular edema.

Authors:  Cagri G Besirli; Mark W Johnson
Journal:  Retin Cases Brief Rep       Date:  2013

6.  Ocular morbidity following renal transplantation.

Authors:  D G Jayamanne; R Porter
Journal:  Nephrol Dial Transplant       Date:  1998-08       Impact factor: 5.992

7.  Rheumatoid hyperviscosity syndrome: reversibility of microvascular abnormalities after treatment.

Authors:  Kourous A Rezai; Samir C Patel; Dean Eliott; Michael A Becker
Journal:  Am J Ophthalmol       Date:  2002-07       Impact factor: 5.258

Review 8.  Posttransplant erythrocytosis.

Authors:  Demetrios V Vlahakos; Katerina P Marathias; Basil Agroyannis; Nicolaos E Madias
Journal:  Kidney Int       Date:  2003-04       Impact factor: 10.612

9.  Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera.

Authors:  Kelly S Rue; Louis K Hirsch; Alfredo A Sadun
Journal:  Clin Ophthalmol       Date:  2012-10-30
  9 in total
  1 in total

Review 1.  Erythrocytosis: genes and pathways involved in disease development.

Authors:  Jernej Gašperšič; Aleša Kristan; Tanja Kunej; Irena Preložnik Zupan; Nataša Debeljak
Journal:  Blood Transfus       Date:  2020-12-16       Impact factor: 3.443

  1 in total

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