Joseph H Friedman1. 1. Dept. of Neurology, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA; Dept of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. Electronic address: joseph_friedman@brown.edu.
Abstract
INTRODUCTION: The question whether DLB and PDD are distinct disorders has been debated in several forums. The two disorders, once parkinsonism is present in DLB, cannot be distinguished on clinical or pathological grounds. The conundrum exists for those DLB patients who do not yet have parkinsonism, and raises the parallel with patients who have Rapid Eye Movement Behavior Disorder but have not yet manifested parkinsonian signs. METHODS: A literature review was summarized to justify classification as a single disorder. RESULTS: Most clinical observations and trials point to these disorders, once parkinsonism is present in DLB, are identical. CONCLUSION: This article notes the advantage to clinical research and treatment by considering these two syndromes as the same so that medications approved for PDD and for PD psychosis can be extended to DLB patients and that resources for PD research and support can be also used for DLB.
INTRODUCTION: The question whether DLB and PDD are distinct disorders has been debated in several forums. The two disorders, once parkinsonism is present in DLB, cannot be distinguished on clinical or pathological grounds. The conundrum exists for those DLB patients who do not yet have parkinsonism, and raises the parallel with patients who have Rapid Eye Movement Behavior Disorder but have not yet manifested parkinsonian signs. METHODS: A literature review was summarized to justify classification as a single disorder. RESULTS: Most clinical observations and trials point to these disorders, once parkinsonism is present in DLB, are identical. CONCLUSION: This article notes the advantage to clinical research and treatment by considering these two syndromes as the same so that medications approved for PDD and for PD psychosis can be extended to DLB patients and that resources for PD research and support can be also used for DLB.
Authors: Dag Aarsland; Lucia Batzu; Glenda M Halliday; Gert J Geurtsen; Clive Ballard; K Ray Chaudhuri; Daniel Weintraub Journal: Nat Rev Dis Primers Date: 2021-07-01 Impact factor: 52.329
Authors: Fabrizia D'Antonio; Maddalena Boccia; Antonella Di Vita; Antonio Suppa; Andrea Fabbrini; Marco Canevelli; Francesca Caramia; Marco Fiorelli; Cecilia Guariglia; Stefano Ferracuti; Carlo de Lena; Dag Aarsland; Dominic Ffytche Journal: J Neurol Date: 2022-01-31 Impact factor: 6.682