Sameeksha Mishra1, Vani Gupta2, Supriya Mishra1, Rekha Sachan3, Akash Asthana4. 1. Department of Physiology, KGMU, Lucknow, UP, India. 2. Department of Physiology, KGMU, Lucknow, UP, India. Electronic address: vaniphysiology@mail.com. 3. Department of Obs. & Gynae, KGMU, Lucknow, UP, India. 4. Department of Statistics, Lucknow University, Lucknow, UP, India.
Abstract
BACKGROUND AND AIMS: Obesity is regulated by different metabolic factors like leptin, adiponectin insulin and neuropeptide orexin-A. The aim of this study is to assess the role of these hormones and their interrelationship with obesity in north Indian women. METHOD: A total of 168 obese women with Body Mass Index (BMI)>30kg/m2 and 150 lean women (BMI<25kg/m2) as control were recruited in this study. Women with obesity were further subdivided into two groups according to their BMI, 71 overweight women with the BMI 25-29.9kg/m2 (mean±S.D: 27.87±0.71) and the 97 obese women with BMI>30kg/m2 (34.68±1.90). Orexin -A, leptin and adiponectin were estimated using quantitative sandwich enzyme linked immunoassay and insulin was estimated by using an immuno-radiometric assay. RESULT: Orexin -A and adiponectin level were significantly lower however, leptin and inulin level were significantly higher in obese women as compared with control group. Further, the one- way group analysis showed that the orexin -A and adiponectin level were significantly lower but leptin and insulin level was significantly higher in obese women as compared to overweight and control group respectively. CONCLUSION: Result showed that the level of adiponectin, leptin, orexin-A and insulin play an important role in the regulation of energy expenditure. In obesity, the activity of these peptides is disturbed.
BACKGROUND AND AIMS: Obesity is regulated by different metabolic factors like leptin, adiponectininsulin and neuropeptide orexin-A. The aim of this study is to assess the role of these hormones and their interrelationship with obesity in north Indian women. METHOD: A total of 168 obesewomen with Body Mass Index (BMI)>30kg/m2 and 150 lean women (BMI<25kg/m2) as control were recruited in this study. Women with obesity were further subdivided into two groups according to their BMI, 71 overweight women with the BMI 25-29.9kg/m2 (mean±S.D: 27.87±0.71) and the 97 obesewomen with BMI>30kg/m2 (34.68±1.90). Orexin -A, leptin and adiponectin were estimated using quantitative sandwich enzyme linked immunoassay and insulin was estimated by using an immuno-radiometric assay. RESULT: Orexin -A and adiponectin level were significantly lower however, leptin and inulin level were significantly higher in obesewomen as compared with control group. Further, the one- way group analysis showed that the orexin -A and adiponectin level were significantly lower but leptin and insulin level was significantly higher in obesewomen as compared to overweight and control group respectively. CONCLUSION: Result showed that the level of adiponectin, leptin, orexin-A and insulin play an important role in the regulation of energy expenditure. In obesity, the activity of these peptides is disturbed.
Authors: Galit L Dunietz; Giancarlo Vanini; Carol Shannon; Louise M O'Brien; Ronald D Chervin Journal: Sleep Med Rev Date: 2020-03-17 Impact factor: 11.609
Authors: Filipe M Ribeiro; Maycon A Silva; Victória Lyssa; Gabriel Marques; Henny K Lima; Octavio L Franco; Bernardo Petriz Journal: Front Endocrinol (Lausanne) Date: 2022-07-28 Impact factor: 6.055