| Literature DB >> 28755588 |
Frilasita A Yudhaputri1, Hidayat Trimarsanto2, Aditya Perkasa1, Benediktus Yohan1, Sotianingsih Haryanto3, Ageng Wiyatno1, Amin Soebandrio1, Khin Saw Myint1, Jeremy P Ledermann4, Ronald Rosenberg4, Ann M Powers4, R Tedjo Sasmono5.
Abstract
Zika virus (ZIKV) JMB-185 strain was isolated from a febrile patient in Jambi, Indonesia in 2014. To understand its genetic characteristics, we performed whole genome sequencing using the Ion Torrent PGM platform on the supernatant of the first passage. The phylogenetic analysis showed that the isolate was not closely related to the Brazilian ZIKV associated with microcephaly or isolates from the recent Singapore Zika outbreak. Molecular evolution analysis indicated that JMB-185 strain may have been circulating in the Southeast Asia region, including Indonesia since 2000. We observed high nucleotide sequence identity between Indonesia, Thailand, Singapore, and American strains although unique amino acid substitutions were also observed. This report provides information on the genomic characteristics of Indonesian ZIKV which may be used for further studies.Entities:
Keywords: Amino acid substitution; Genome; Indonesia; Zika virus
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Year: 2017 PMID： 28755588 PMCID： PMC5747357 DOI： 10.1016/j.virol.2017.07.026
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616