| Literature DB >> 28755516 |
David J Margolis1, Michelle Hampton1, Ole Hoffstad1, D Scot Mala2, Ziad Mirza3, Diana Woltereck3, Steven Shannon2, Michael A Troiano2, Nandita Mitra4, Ming Yang5, Veena M Bhopale5, Stephen R Thom5.
Abstract
It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that NOS1AP variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it NOS1AP might be associated with a functional impairment.Entities:
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Year: 2017 PMID： 28755516 PMCID： PMC5747323 DOI： 10.1111/wrr.12564
Source DB: PubMed Journal: Wound Repair Regen ISSN： 1067-1927 Impact factor: 3.617