Literature DB >> 28754532

Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.

C Borrás1, E Serna1, J Gambini1, M Inglés1, J Vina2.   

Abstract

Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  DICER; DROSHA; EXPORTIN 5; Health span; Longevity; RNA POL II

Mesh：

Substances：

Year:  2017        PMID： 28754532     DOI： 10.1016/j.mad.2017.07.003

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  10 in total

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4.  Dicer1 deficient mice exhibit premature aging and metabolic perturbations in adipocytes.

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5.  Plasma methionine metabolic profile is associated with longevity in mammals.

Authors:  N Mota-Martorell; M Jové; R Berdún; R Pamplona
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Authors:  Sabel Meadows; Abbagael Seidler; Madison Wall; Jamika Page; Cara Taylor; Brendin Flinn; Robin Turner; Nalini Santanam
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Review 10.  The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging.

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  10 in total

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