Literature DB >> 28752851

A key HDAC6 dependency of ARID1A-mutated ovarian cancer.

Lucia Altucci1.   

Abstract

Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.

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Year:  2017        PMID： 28752851     DOI： 10.1038/ncb3588

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

Review 1.  The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease.

Authors:  Sri N Batchu; Angela S Brijmohan; Andrew Advani
Journal:  Clin Sci (Lond)       Date:  2016-06-01       Impact factor: 6.124

2.  Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Authors:  Siân Jones; Tian-Li Wang; Ie-Ming Shih; Tsui-Lien Mao; Kentaro Nakayama; Richard Roden; Ruth Glas; Dennis Slamon; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Journal:  Science       Date:  2010-09-08       Impact factor: 47.728

Review 3.  Epigenetic Therapeutics: A New Weapon in the War Against Cancer.

Authors:  Nita Ahuja; Anup R Sharma; Stephen B Baylin
Journal:  Annu Rev Med       Date:  2016       Impact factor: 13.739

4.  Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Authors:  Cigall Kadoch; Diana C Hargreaves; Courtney Hodges; Laura Elias; Lena Ho; Jeff Ranish; Gerald R Crabtree
Journal:  Nat Genet       Date:  2013-05-05       Impact factor: 38.330

5.  Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors:  Maria E Figueroa; Omar Abdel-Wahab; Chao Lu; Patrick S Ward; Jay Patel; Alan Shih; Yushan Li; Neha Bhagwat; Aparna Vasanthakumar; Hugo F Fernandez; Martin S Tallman; Zhuoxin Sun; Kristy Wolniak; Justine K Peeters; Wei Liu; Sung E Choe; Valeria R Fantin; Elisabeth Paietta; Bob Löwenberg; Jonathan D Licht; Lucy A Godley; Ruud Delwel; Peter J M Valk; Craig B Thompson; Ross L Levine; Ari Melnick
Journal:  Cancer Cell       Date:  2010-12-09       Impact factor: 38.585

6.  Integrated genomic analyses of ovarian carcinoma.

Authors: 
Journal:  Nature       Date:  2011-06-29       Impact factor: 49.962

7.  Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.

Authors:  Mamiko Sakata-Yanagimoto; Terukazu Enami; Kenichi Yoshida; Yuichi Shiraishi; Ryohei Ishii; Yasuyuki Miyake; Hideharu Muto; Naoko Tsuyama; Aiko Sato-Otsubo; Yusuke Okuno; Seiji Sakata; Yuhei Kamada; Rie Nakamoto-Matsubara; Nguyen Bich Tran; Koji Izutsu; Yusuke Sato; Yasunori Ohta; Junichi Furuta; Seiichi Shimizu; Takuya Komeno; Yuji Sato; Takayoshi Ito; Masayuki Noguchi; Emiko Noguchi; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Kazumi Suzukawa; Toru Nanmoku; Yuichi Hasegawa; Osamu Nureki; Satoru Miyano; Naoya Nakamura; Kengo Takeuchi; Seishi Ogawa; Shigeru Chiba
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 41.307

8.  The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

Authors:  Peter M K Westcott; Kyle D Halliwill; Minh D To; Mamunur Rashid; Alistair G Rust; Thomas M Keane; Reyno Delrosario; Kuang-Yu Jen; Kay E Gurley; Christopher J Kemp; Erik Fredlund; David A Quigley; David J Adams; Allan Balmain
Journal:  Nature       Date:  2014-11-02       Impact factor: 49.962

9.  ARID1A-mutated ovarian cancers depend on HDAC6 activity.

Authors:  Benjamin G Bitler; Shuai Wu; Pyoung Hwa Park; Yang Hai; Katherine M Aird; Yemin Wang; Yali Zhai; Andrew V Kossenkov; Ana Vara-Ailor; Frank J Rauscher; Weiping Zou; David W Speicher; David G Huntsman; Jose R Conejo-Garcia; Kathleen R Cho; David W Christianson; Rugang Zhang
Journal:  Nat Cell Biol       Date:  2017-07-24       Impact factor: 28.824

10.  Comprehensive identification of mutational cancer driver genes across 12 tumor types.

Authors:  David Tamborero; Abel Gonzalez-Perez; Christian Perez-Llamas; Jordi Deu-Pons; Cyriac Kandoth; Jüri Reimand; Michael S Lawrence; Gad Getz; Gary D Bader; Li Ding; Nuria Lopez-Bigas
Journal:  Sci Rep       Date:  2013-10-02       Impact factor: 4.379
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  1 in total

1.  A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening.

Authors:  Youngran Park; Jin-Gyoung Jung; Zheng-Cheng Yu; Ryoichi Asaka; Wenjing Shen; Yeh Wang; Wei-Hung Jung; Alicja Tomaszewski; Geoff Shimberg; Yun Chen; Vamsi Parimi; Stephanie Gaillard; Ie-Ming Shih; Tian-Li Wang
Journal:  Lab Invest       Date:  2021-08-10       Impact factor: 5.662
  1 in total

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