Nicholas Larkins1,2, Armando Teixeira-Pinto3,4, Jonathan Craig3,4. 1. Department of Nephrology, Princess Margaret Hospital, Subiaco, WA, 6008, Australia. nicholas.larkins@health.wa.gov.au. 2. Sydney School of Public Health, University of Sydney, Sydney, Australia. nicholas.larkins@health.wa.gov.au. 3. Sydney School of Public Health, University of Sydney, Sydney, Australia. 4. Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Abstract
OBJECTIVES: To determine the population-based prevalence of albuminuria in Australian children and validate any negative correlation with body mass index (BMI). METHODS: Data from the Australian Health Survey 2011-2013 were used. This is a large-scale survey of the health of the Australian population, conducted by the Australian Bureau of Statistics, and uses a stratified, multistage area design with replicate weights attached to observations to allow for the derivation of accurate population estimates. We considered children aged 5-18 years, and defined albuminuria as an albumin-to-creatinine ratio (ACR) >30 mg/g (3.4 mg/mmol). RESULTS: A total of 975 children provided urine samples for determination of ACR. The prevalence of albuminuria was 10.2% for males (95% confidence interval [CI] 6.1-14.2) and 15.5% for females (95% CI 10.7-20.3). After adjusting for age and gender, the odds ratio for albuminuria associated with being overweight or obese was 0.34 (95% CI 0.15-0.75). This relationship also held for waist-to-height ratio, where the adjusted odds ratio for each 0.1 increase was 0.46 (95% CI 0.26-0.82). CONCLUSIONS: Albuminuria, using a measurement suitable for population-based and clinical screening, occurs in 12.8% of school-aged Australian children, and is less common in overweight and obese children.
OBJECTIVES: To determine the population-based prevalence of albuminuria in Australian children and validate any negative correlation with body mass index (BMI). METHODS: Data from the Australian Health Survey 2011-2013 were used. This is a large-scale survey of the health of the Australian population, conducted by the Australian Bureau of Statistics, and uses a stratified, multistage area design with replicate weights attached to observations to allow for the derivation of accurate population estimates. We considered children aged 5-18 years, and defined albuminuria as an albumin-to-creatinine ratio (ACR) >30 mg/g (3.4 mg/mmol). RESULTS: A total of 975 children provided urine samples for determination of ACR. The prevalence of albuminuria was 10.2% for males (95% confidence interval [CI] 6.1-14.2) and 15.5% for females (95% CI 10.7-20.3). After adjusting for age and gender, the odds ratio for albuminuria associated with being overweight or obese was 0.34 (95% CI 0.15-0.75). This relationship also held for waist-to-height ratio, where the adjusted odds ratio for each 0.1 increase was 0.46 (95% CI 0.26-0.82). CONCLUSIONS:Albuminuria, using a measurement suitable for population-based and clinical screening, occurs in 12.8% of school-aged Australian children, and is less common in overweight and obesechildren.
Entities:
Keywords:
Albuminuria; Child; Health surveys; Kidney
Authors: H C Gerstein; J F Mann; Q Yi; B Zinman; S F Dinneen; B Hoogwerf; J P Hallé; J Young; A Rashkow; C Joyce; S Nawaz; S Yusuf Journal: JAMA Date: 2001-07-25 Impact factor: 56.272
Authors: Robert C Atkins; Kevan R Polkinghorne; Esther M Briganti; Jonathan E Shaw; Paul Z Zimmet; Steven J Chadban Journal: Kidney Int Suppl Date: 2004-11 Impact factor: 10.545
Authors: Erick Sierra-Diaz; Alfredo de Jesus Celis-de la Rosa; Felipe Lozano-Kasten; Alejandro Bravo-Cuellar; Mariana Garcia-Gutierrez; Hernandez-Flores Georgina Journal: Int J Environ Res Public Health Date: 2017-10-16 Impact factor: 3.390
Authors: Sophie Marielle van den Belt; Valentina Gracchi; Dick de Zeeuw; Hiddo Jan Lambers Heerspink Journal: PLoS One Date: 2018-06-21 Impact factor: 3.240
Authors: Nicholas G Larkins; Siah Kim; John B Carlin; Anneke C Grobler; David P Burgner; Katherine Lange; Jonathan C Craig; Melissa Wake Journal: BMJ Open Date: 2019-07-04 Impact factor: 2.692
Authors: Felipe Lozano-Kasten; Erick Sierra-Diaz; Alfredo de Jesus Celis-de la Rosa; María Margarita Soto Gutiérrez; Alejandro Aarón Peregrina Lucano Journal: Int J Environ Res Public Health Date: 2017-12-14 Impact factor: 3.390