| Literature DB >> 28751609 |
Zirong Gu1, John Kalambogias2,3, Shin Yoshioka1, Wenqi Han4, Zhuo Li4,5, Yuka Imamura Kawasawa4,6, Sirisha Pochareddy4, Zhen Li4, Fuchen Liu4, Xuming Xu4, H. R. Sagara Wijeratne7, Masaki Ueno1,8, Emily Blatz1, Joseph Salomone1, Atsushi Kumanogoh9, Mladen-Roko Rasin7, Brian Gebelein1, Matthew T Weirauch10, Nenad Sestan4, John H Martin11,3, Yutaka Yoshida12.
Abstract
Superior manual dexterity in higher primates emerged together with the appearance of cortico-motoneuronal (CM) connections during the evolution of the mammalian corticospinal (CS) system. Previously thought to be specific to higher primates, we identified transient CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling. PlexA1 mutant mice maintain CM connections into adulthood and exhibit superior manual dexterity as compared with that of controls. Last, differing PlexA1 expression in layer 5 of the motor cortex, which is strong in wild-type mice but weak in humans, may be explained by FEZF2-mediated cis-regulatory elements that are found only in higher primates. Thus, species-dependent regulation of PlexA1 expression may have been crucial in the evolution of mammalian CS systems that improved fine motor control in higher primates.Entities:
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Year: 2017 PMID： 28751609 PMCID： PMC5774341 DOI： 10.1126/science.aan3721
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728