Literature DB >> 2875160

Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria.

E E Essien, E I Ette.   

Abstract

The effects of chloroquine and didesethylchloroquine on the rabbit isolated perfused heart and on calcium binding and accumulating ability of the heart mitochondria were investigated. The drugs produced negative chronotropy, negative inotropy and a decrease in coronary flow rate in the isolated perfused myocardium. Both chloroquine and didesethylchloroquine significantly decreased mitochondrial calcium binding and accumulation. These results suggest that the cardiodepressant actions of chloroquine could be due in part to alterations in the calcium accumulating abilities of the mitochondrial membranes, and that didesethylchloroquine, among other metabolites, does contribute significantly to the total observed effect of chloroquine on the cardiovascular system.

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Year:  1986        PMID： 2875160     DOI： 10.1111/j.2042-7158.1986.tb04635.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  12 in total

Review 1.  Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.

Authors:  J Ducharme; R Farinotti
Journal:  Clin Pharmacokinet       Date:  1996-10       Impact factor: 6.447

2.  Effects of mefloquine on cardiac contractility and electrical activity in vivo, in isolated cardiac preparations, and in single ventricular myocytes.

Authors:  S J Coker; A J Batey; I D Lightbown; M E Díaz; D A Eisner
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

3.  Inhibition of cardiac Na+ current by primaquine.

Authors:  Gerardo Orta-Salazar; Ron A Bouchard; Fernando Morales-Salgado; Eduardo M Salinas-Stefanon
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

4.  Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers.

Authors:  Irwin Law; Kenneth F Ilett; L Peter Hackett; Madhu Page-Sharp; Francesca Baiwog; Servina Gomorrai; Ivo Mueller; Harin A Karunajeewa; Timothy M E Davis
Journal:  Br J Clin Pharmacol       Date:  2008-02-15       Impact factor: 4.335

5.  Effect of antimalarials treatment on rat liver lysosomal function-Anin vivo study.

Authors:  Samir P Patel; Subhash D Katewa; Surendra S Katyare
Journal:  Indian J Clin Biochem       Date:  2005-01

6.  Chloroquine disposition in hypersensitive and non-hypersensitive subjects and its significance in chloroquine-induced pruritus.

Authors:  E E Essien; E I Ette; W O Thomas; E A Brown-Awala
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Jan-Mar       Impact factor: 2.441

7.  Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis.

Authors:  P Augustijns; P Geusens; N Verbeke
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

8.  Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: effects of chloroquine.

Authors:  Karthik Dhanabalan; Barbara Huisamen; Amanda Lochner
Journal:  Cardiovasc J Afr       Date:  2019-12-12       Impact factor: 1.167

9.  High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.

Authors:  Antoine H Chaanine; Ronald E Gordon; Mathieu Nonnenmacher; Erik Kohlbrenner; Ludovic Benard; Roger J Hajjar
Journal:  Physiol Rep       Date:  2015-07

Review 10.  Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties.

Authors:  Cornelis Smit; Mariska Y M Peeters; John N van den Anker; Catherijne A J Knibbe
Journal:  Clin Pharmacokinet       Date:  2020-06       Impact factor: 6.447
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