Rick van der Vliet1, Gerard M Ribbers2, Yves Vandermeeren3, Maarten A Frens4, Ruud W Selles5. 1. Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands; Department of Rehabilitation Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address: r.vandervliet@erasmusmc.nl. 2. Department of Rehabilitation Medicine, Erasmus MC, Rotterdam, The Netherlands; Rijndam Rehabilitation Center, Rotterdam, The Netherlands. 3. Université Catholique de Louvain (UCL), CHU UCL Namur, Neurology Department, Stroke Unit, NeuroModulation Unit (NeMU), Yvoir, Belgium; Université Catholique de Louvain (UCL), Institute of NeuroScience (IoNS), Brussels, Belgium; Université Catholique de Louvain (UCL), Louvain Bionics, Louvain-la-Neuve, Belgium. 4. Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands; Erasmus University College, Rotterdam, The Netherlands. 5. Department of Rehabilitation Medicine, Erasmus MC, Rotterdam, The Netherlands; Rijndam Rehabilitation Center, Rotterdam, The Netherlands; Department of Plastic and Reconstructive Surgery, Erasmus MC, Rotterdam, The Netherlands.
Abstract
BACKGROUND:tDCS is a non-invasive neuromodulation technique that has been reported to improve motor skill learning after stroke. However, the contribution of tDCS to motor skill learning has only been investigated in a small number of studies. In addition, it is unclear if tDCS effects are mediated by activity-dependent BDNF release and dependent on timing of tDCS relative to training. OBJECTIVE: Investigate the role of activity-dependent BDNF release and timing of tDCS relative to training in motor skill learning. METHODS: Double-blind, between-subjects randomized controlled trial of circuit tracing task improvement (ΔMotor skill) in 80 chronic stroke patients who underwent tDCS and were genotyped for BDNF Val66Met. Patients received either short-lasting tDCS (20 min) during training (short-lasting online group), long-lasting tDCS (10 min-25 min break - 10 min) one day before training (long-lasting offline group), short-lasting tDCS one day before training (short-lasting offline group), or shamtDCS. ΔMotor skill was defined as the skill difference on the circuit tracing task between day one and day nine of the study. RESULTS: Having at least one BDNF Met allele was found to diminish ΔMotor skill (βBDNF,Met = -0.217 95%HDI = [-0.431 -0.0116]), indicating activity-dependent BDNF release is important for motor skill learning after stroke. However, none of the tDCS protocols affected ΔMotor skill (βShort-lasting,online = 0.0908 95%HDI = [-0.227 0.403]; βLong-lasting,offline = 0.0242 95%HDI = [-0.292 0.349]; βShort-lasting,offline = -0.108 95%HDI = [-0.433 0.210]). CONCLUSION: BDNF Val66Met is a determinant of motor skill learning after stroke and could be important for prognostic models. tDCS does not modulate motor skill learning in our study and might be less effective than previously assumed.
RCT Entities:
BACKGROUND: tDCS is a non-invasive neuromodulation technique that has been reported to improve motor skill learning after stroke. However, the contribution of tDCS to motor skill learning has only been investigated in a small number of studies. In addition, it is unclear if tDCS effects are mediated by activity-dependent BDNF release and dependent on timing of tDCS relative to training. OBJECTIVE: Investigate the role of activity-dependent BDNF release and timing of tDCS relative to training in motor skill learning. METHODS: Double-blind, between-subjects randomized controlled trial of circuit tracing task improvement (ΔMotor skill) in 80 chronic strokepatients who underwent tDCS and were genotyped for BDNF Val66Met. Patients received either short-lasting tDCS (20 min) during training (short-lasting online group), long-lasting tDCS (10 min-25 min break - 10 min) one day before training (long-lasting offline group), short-lasting tDCS one day before training (short-lasting offline group), or sham tDCS. ΔMotor skill was defined as the skill difference on the circuit tracing task between day one and day nine of the study. RESULTS: Having at least one BDNF Met allele was found to diminish ΔMotor skill (βBDNF,Met = -0.217 95%HDI = [-0.431 -0.0116]), indicating activity-dependent BDNF release is important for motor skill learning after stroke. However, none of the tDCS protocols affected ΔMotor skill (βShort-lasting,online = 0.0908 95%HDI = [-0.227 0.403]; βLong-lasting,offline = 0.0242 95%HDI = [-0.292 0.349]; βShort-lasting,offline = -0.108 95%HDI = [-0.433 0.210]). CONCLUSION:BDNF Val66Met is a determinant of motor skill learning after stroke and could be important for prognostic models. tDCS does not modulate motor skill learning in our study and might be less effective than previously assumed.
Authors: Shreya Parchure; Denise Y Harvey; Priyanka P Shah-Basak; Laura DeLoretta; Rachel Wurzman; Daniela Sacchetti; Olufunsho Faseyitan; Falk W Lohoff; Roy H Hamilton Journal: Neuromodulation Date: 2021-07-12
Authors: Joris Van der Cruijsen; Zeb D Jonker; Eleni-Rosalina Andrinopoulou; Jessica E Wijngaarden; Ditte A Tangkau; Joke H M Tulen; Maarten A Frens; Gerard M Ribbers; Ruud W Selles Journal: Front Hum Neurosci Date: 2022-05-04 Impact factor: 3.473
Authors: Shreya Parchure; Denise Y Harvey; Priyanka P Shah-Basak; Laura DeLoretta; Rachel Wurzman; Daniela Sacchetti; Olufunsho Faseyitan; Falk W Lohoff; Roy H Hamilton Journal: Neuromodulation Date: 2021-07-12