Literature DB >> 28751145

Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety.

Zhenzhen Wang1, Dandan Xie1, Xiuhai Gan1, Song Zeng1, Awei Zhang1, Limin Yin1, Baoan Song1, Linhong Jin2, Deyu Hu3.   

Abstract

In this study, we report the synthesis and antiviral activity of trans-ferulic acid derivatives containing acylhydrazone moiety. Biological tests demonstrated that most target compounds showed potent antiviral activity against tobacco mosaic virus (TMV). Compound D4 showed remarkable inactivating activity with EC50 value of 36.59μg/mL, which was obviously superior to ribavirin (126.05μg/mL). Molecular docking results revealed that compound D4 exhibited the optimal combining capacity with five hydrogen bonds to different amino-acid residues of TMV coat protein (TMV-CP). Docking results were consistent with the inactivating activity of target compounds against TMV.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Acylhydrazone; Antiviral activity; Ferulic acid derivatives; Molecular docking; TMV-CP

Mesh：

Substances：

Year:  2017        PMID： 28751145     DOI： 10.1016/j.bmcl.2017.07.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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Journal:  RSC Adv       Date:  2019-10-10       Impact factor: 4.036

7.  The Inhibitory Potential of Ferulic Acid Derivatives against the SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and ADMET Evaluation.

Authors:  Io Antonopoulou; Eleftheria Sapountzaki; Ulrika Rova; Paul Christakopoulos
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8.  Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides.

Authors:  Xiaobin Wang; Zhengjiao Ren; Mengqi Wang; Min Chen; Aiming Lu; Weijie Si; Chunlong Yang
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9.  Discovery of Dithioacetal Derivatives Containing Sulfonamide Moiety of Novel Antiviral Agents by TMV Coat Protein as a Potential Target.

Authors:  Yuyuan Yang; Jian Zhang; Xiangyang Li; Fangcheng He; Rong Wu; Deyu Hu; Baoan Song
Journal:  ACS Omega       Date:  2020-08-26
  9 in total

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