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Literature DB >> 28750950

New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis.

Abstract

The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.

Entities: Chemical Disease Species

Keywords: Cryptosporidium; children; diarrhea; drug discovery; immunocompromised

Mesh：

Substances：
KDU731
Pyrazoles
Pyridines

Year: 2017 PMID： 28750950 DOI： 10.1016/j.pt.2017.07.004

Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922

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Cited

6 in total

1. Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection.

Authors: Anoop Kumar; Dulari Jayawardena; Arivarasu N Anbazhagan; Ishita Chatterjee; Shubha Priyamvada; Waddah A Alrefai; Alip Borthakur; Pradeep K Dudeja
Journal: Am J Physiol Cell Physiol Date: 2019-09-04 Impact factor: 4.249

2. Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins.

Authors: Anoop Kumar; Ishita Chatterjee; Arivarasu N Anbazhagan; Dulari Jayawardena; Shubha Priyamvada; Waddah A Alrefai; Jun Sun; Alip Borthakur; Pradeep K Dudeja
Journal: Cell Microbiol Date: 2018-03-23 Impact factor: 3.715

New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis.

1. Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection.

2. Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins.

3. Cryptosporidium parvum infection induces autophagy in intestinal epithelial cells.

Review 4. Recent Breakthroughs and Ongoing Limitations in Cryptosporidium Research.

5. Comparative analyses of parasites with a comprehensive database of genome-scale metabolic models.

6. Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture.