| Literature DB >> 28749761 |
Stella M Chenet1, Luciana Silva-Flannery2, Naomi W Lucchi1, Ljolje Dragan2, Emilio Dirlikov3,4, Kimberly Mace1, Brenda Rivera-García3, Paul M Arguin1, Venkatachalam Udhayakumar1.
Abstract
The Caribbean island of Hispaniola is targeted for malaria elimination. Currently, this is the only island with ongoing transmission of malaria in the Caribbean. In 2015, six patients from Puerto Rico and one from Massachusetts, who traveled to Punta Cana, Dominican Republic, were confirmed to be infected with Plasmodium falciparum. Additional molecular analysis was performed at the Centers for Disease Control and Prevention to characterize the drug-resistant alleles and Plasmodium population genetic markers. All specimens carried wildtype genotypes for chloroquine, sulfadoxine-pyrimethamine, and artemisinin resistance genetic markers. A mutation in codon 184 (Y/F) of Pfmdr-1 gene was observed in all samples and they shared an identical genetic lineage as determined by microsatellite analysis. This genetic profile was similar to one previously reported from Hispaniola suggesting that a clonal P. falciparum residual parasite population present in Punta Cana is the source population for these imported malaria cases.Entities:
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Year: 2017 PMID： 28749761 PMCID： PMC5590579 DOI： 10.4269/ajtmh.16-0837
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345