Literature DB >> 28749598

Beyond Farnesoid X receptor to target new therapies for NAFLD.

Xiaoying Liu1, Richard M Green1.   

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Year:  2017        PMID： 28749598      PMCID： PMC6032979          DOI： 10.1002/hep.29411

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


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  10 in total

1.  Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

Authors:  Mitsuhiro Watanabe; Yasushi Horai; Sander M Houten; Kohkichi Morimoto; Taichi Sugizaki; Eri Arita; Chikage Mataki; Hiroyuki Sato; Yusuke Tanigawara; Kristina Schoonjans; Hiroshi Itoh; Johan Auwerx
Journal:  J Biol Chem       Date:  2011-06-01       Impact factor: 5.157

2.  Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

Authors:  Yanqiao Zhang; Florence Ying Lee; Gabriel Barrera; Hans Lee; Charisse Vales; Frank J Gonzalez; Timothy M Willson; Peter A Edwards
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-12       Impact factor: 11.205

3.  Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner.

Authors:  Young Joo Park; Seong Chul Kim; Jeehee Kim; Sayeepriyadarshini Anakk; Jae Man Lee; Hsiu-Ting Tseng; Vijay Yechoor; Junchol Park; June-Seek Choi; Hak Chul Jang; Ki-Up Lee; Colleen M Novak; David D Moore; Yoon Kwang Lee
Journal:  J Lipid Res       Date:  2011-09-23       Impact factor: 5.922

4.  Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.

Authors:  Sayeepriyadarshini Anakk; Mitsuhiro Watanabe; Scott A Ochsner; Neil J McKenna; Milton J Finegold; David D Moore
Journal:  J Clin Invest       Date:  2010-12-01       Impact factor: 14.808

5.  The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.

Authors:  Li Wang; Jun Liu; Pradip Saha; Jiansheng Huang; Lawrence Chan; Bruce Spiegelman; David D Moore
Journal:  Cell Metab       Date:  2005-10       Impact factor: 27.287

6.  Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.

Authors:  Preeti Pathak; Hailiang Liu; Shannon Boehme; Cen Xie; Kristopher W Krausz; Frank Gonzalez; John Y L Chiang
Journal:  J Biol Chem       Date:  2017-05-06       Impact factor: 5.157

7.  Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.

Authors:  Oludemilade Akinrotimi; Ryan Riessen; Philip VanDuyne; Jung Eun Park; Yoon Kwang Lee; Lee-Jun Wong; Ann M Zavacki; Kristina Schoonjans; Sayeepriyadarshini Anakk
Journal:  Hepatology       Date:  2017-10-30       Impact factor: 17.425

8.  Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.

Authors:  Kang Ho Kim; Sungwoo Choi; Ying Zhou; Eun Young Kim; Jae Man Lee; Pradip K Saha; Sayeepriyadarshini Anakk; David D Moore
Journal:  Hepatology       Date:  2017-06-26       Impact factor: 17.425

9.  Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

Authors:  Changtao Jiang; Cen Xie; Fei Li; Limin Zhang; Robert G Nichols; Kristopher W Krausz; Jingwei Cai; Yunpeng Qi; Zhong-Ze Fang; Shogo Takahashi; Naoki Tanaka; Dhimant Desai; Shantu G Amin; Istvan Albert; Andrew D Patterson; Frank J Gonzalez
Journal:  J Clin Invest       Date:  2014-12-15       Impact factor: 14.808

10.  Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Authors:  Sungsoon Fang; Jae Myoung Suh; Shannon M Reilly; Elizabeth Yu; Olivia Osborn; Denise Lackey; Eiji Yoshihara; Alessia Perino; Sandra Jacinto; Yelizaveta Lukasheva; Annette R Atkins; Alexander Khvat; Bernd Schnabl; Ruth T Yu; David A Brenner; Sally Coulter; Christopher Liddle; Kristina Schoonjans; Jerrold M Olefsky; Alan R Saltiel; Michael Downes; Ronald M Evans
Journal:  Nat Med       Date:  2015-01-05       Impact factor: 53.440
  10 in total
  1 in total

1.  SREBP-2, a new target of metformin?

Authors:  Fengxia Zhang; Wenxiu Sun; Jianbo Chen; Lusheng Jiang; Ping Yang; Yufang Huang; Aihua Gong; Shudong Liu; Shizhan Ma
Journal:  Drug Des Devel Ther       Date:  2018-12-06       Impact factor: 4.162
  1 in total

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