Ana María Leiva1, María Adela Martínez2, Carlos Cristi-Montero3, Carlos Salas4, Rodrigo Ramírez-Campillo5, Ximena Díaz Martínez6, Nicolás Aguilar-Farías7, Carlos Celis-Morales8. 1. Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. 2. Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile. 3. Grupo IRyS, Escuela de Educación Física, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. 4. Departamento de Educación Física, Facultad de Educación, Universidad de Concepción, Concepción, Chile. 5. Departamento de Ciencias de la Actividad Física, Universidad de Los Lagos, Osorno, Chile. 6. Grupo de Investigación Calidad de Vida y Estilos de Vida Saludable, Universidad del Biobío, Chillán, Chile. 7. Departamento de Educación Física, Deportes y Recreación, Universidad de Temuco, Temuco, Chile. 8. Human Nutrition Research Centre, Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom.
Abstract
BACKGROUND: Sedentary behavior is a main risk factor for cardiovascular disease and mortality. AIM: To investigate the association between sedentary behavior and metabolic and cardiovascular risk factors. MATERIAL AND METHODS: We assessed 322 participants aged between 18 to 65 years. Physical activity and sedentary behavior were measured with accelerometers (Actigraph®). Body mass index (BMI), waist circumference, percentage of body fat, diet and blood markers (glucose, lipid profile, insulin and HOMA-IR) were measured with standardized protocols. RESULTS: Thirty four percent of participants were physically inactive and spent on average 8.7 h/day on sedentary activities. Per one hour increase in sedentary behavior there were significant adverse changes in glucose (4.79 mg/dl), insulin (2.73 pmol/l), HOMA-IR (0.75), BMI (0.69 kg/m²), waist circumference (1.95 cm), fat mass (1.03%), total cholesterol (9.73 mg/dl), HDL-cholesterol (-3.50 mg/dl), LDL-cholesterol (10.7 mg/dl) and triglycerides (12.4 mg/dl). These findings were independent of main confounding factors including total physical activity, dietary factors, BMI and socio-demographics. CONCLUSIONS: The detrimental effect of sedentary behaviors on cardiometabolic and obesity-related traits is independent of physical activity levels. Therefore, reducing sedentary time should be targeted in the population apart from increasing their physical activity levels.
BACKGROUND: Sedentary behavior is a main risk factor for cardiovascular disease and mortality. AIM: To investigate the association between sedentary behavior and metabolic and cardiovascular risk factors. MATERIAL AND METHODS: We assessed 322 participants aged between 18 to 65 years. Physical activity and sedentary behavior were measured with accelerometers (Actigraph®). Body mass index (BMI), waist circumference, percentage of body fat, diet and blood markers (glucose, lipid profile, insulin and HOMA-IR) were measured with standardized protocols. RESULTS: Thirty four percent of participants were physically inactive and spent on average 8.7 h/day on sedentary activities. Per one hour increase in sedentary behavior there were significant adverse changes in glucose (4.79 mg/dl), insulin (2.73 pmol/l), HOMA-IR (0.75), BMI (0.69 kg/m²), waist circumference (1.95 cm), fat mass (1.03%), total cholesterol (9.73 mg/dl), HDL-cholesterol (-3.50 mg/dl), LDL-cholesterol (10.7 mg/dl) and triglycerides (12.4 mg/dl). These findings were independent of main confounding factors including total physical activity, dietary factors, BMI and socio-demographics. CONCLUSIONS: The detrimental effect of sedentary behaviors on cardiometabolic and obesity-related traits is independent of physical activity levels. Therefore, reducing sedentary time should be targeted in the population apart from increasing their physical activity levels.