| Literature DB >> 28748449 |
Marzia Puccioni-Sohler1,2,3, Alice M M Ornelas4, Andrea S de Souza5, Mauro Jorge Cabral-Castro4, Jessyca T M A Ramos6, Carolina Rosadas4, Maria Cecilia F Salgado6, Alexandre A Castiglione7, Fernando Ferry6, Jose Mauro Peralta4, Carolina Moreira Voloch4, Amilcar Tanuri4, Fernanda Tovar-Moll4,5, Renato Santana Aguiar4.
Abstract
Dengue virus (DENV) causes immune-mediated diseases. Neurological involvement represents a severe condition that is rarely observed in DENV-1 infection. Neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) are idiopathic immune-mediated demyelinating syndromes of the central nervous system. We report a 17-year-old female with oligosymptomatic DENV-1 viremia, diagnosed as NMOSD. Magnetic resonance imaging showed spinal cord and brainstem lesions. Antibody for aquaporin 4 was negative. DENV-1 RNA infection was detected by serial RT-PCR and confirmed by phylogenetic analysis in serum. Although there are some reports of NMO post-dengue infection, there are not any published accounts of NMOSD with coexistent and persistent DENV-1 infection.Entities:
Keywords: Cerebrospinal fluid; Dengue virus; Magnetic resonance imaging; Neuromyelitis optica spectrum disorder
Mesh：
Year: 2017 PMID： 28748449 DOI： 10.1007/s13365-017-0555-7
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643