Literature DB >> 2874658

Flow cytometric DNA measurements in human thyroid tumors.

K Christov.   

Abstract

By means of flow cytometry (FCM), DNA distribution pattern and the fraction of cells in the various phases of the cell cycle were studied in 52 samples of normal thyroid tissues, follicular adenomas, follicular carcinomas, medullary carcinoma and fibrosarcomas. In the normal thyroid tissues and follicular adenomas DNA diploid cell populations only were found. Among 20 follicular carcinomas in 13 cases (65%) together with the DNA diploid cells, DNA aneuploid cell lines were also observed. S-phase fraction in follicular adenomas is higher than in the normal thyroid tissues and lower than those in thyroid carcinomas. The percentage of S-phase cells in DNA aneuploid populations is significantly higher (S = 19 +/- 9.3%) than in the diploid cell lines (S = 3.7 +/- 2.6%). DNA aneuploid cell populations were predominantly observed in carcinomas with a high degree of morphological anaplasia.

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Year:  1986        PMID： 2874658     DOI： 10.1007/bf02899035

Source DB:  PubMed          Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol        ISSN： 0340-6075


  9 in total

Review 1.  The utility of some modern techniques in understanding thyroid pathology.

Authors:  Virginia A LiVoisi
Journal:  Endocr Pathol       Date:  1990-06       Impact factor: 3.943

Review 2.  The study of endocrine tumors by flow and image cytometry.

Authors:  Ingrid Zbieranowski; David Murray
Journal:  Endocr Pathol       Date:  1992-06       Impact factor: 3.943

3.  Flow cytometric DNA analysis of thyroid carcinoma.

Authors:  A Tsuchiya; K Sekikawa; Y Ando; S Suzuki; I Kimijima; R Abe
Journal:  Jpn J Surg       Date:  1990-09

4.  Value of quantitative nucleolar features in the preoperative cytological diagnosis of follicular neoplasias of the thyroid.

Authors:  R Montironi; A Braccischi; M Scarpelli; G Matera; R Alberti
Journal:  J Clin Pathol       Date:  1991-06       Impact factor: 3.411

5.  Reproducibility of flow cytometric assessment of follicular tumours of the thyroid.

Authors:  T P van Thiel; J C van der Linden; J P Baak; M M van de Sandt; C van Galen; P D Bezemer
Journal:  J Clin Pathol       Date:  1989-03       Impact factor: 3.411

6.  Diagnostic and prognostic utility of flow cytometric DNA measurements in follicular thyroid tumors.

Authors:  C S Grant; I D Hay; J J Ryan; E J Bergstralh; L M Rainwater; J R Goellner
Journal:  World J Surg       Date:  1990 May-Jun       Impact factor: 3.352

7.  Nuclear DNA analysis and prognosis in carcinoma of the thyroid gland. A nationwide study in Iceland on carcinomas diagnosed 1955-1990.

Authors:  J G Jónasson; J Hrafnkelsson
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

8.  DNA aneuploidy in adenomas of endocrine organs.

Authors:  H Joensuu; P J Klemi
Journal:  Am J Pathol       Date:  1988-07       Impact factor: 4.307

9.  Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.

Authors:  Thomas J Wubben; Mercy Pawar; Eric Weh; Andrew Smith; Peter Sajjakulnukit; Li Zhang; Lipeng Dai; Heather Hager; Manjunath P Pai; Costas A Lyssiotis; Cagri G Besirli
Journal:  Sci Rep       Date:  2020-02-19       Impact factor: 4.379
  9 in total

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