Chante Karimkhani1, Robert P Dellavalle2, Seyed M Karimi3, Vafa Rahimi-Movaghar4, Farshad Pourmalek5, Aliasghar A Kiadaliri6, Mohammad Ali Sahraian7, Gholamreza Roshandel8, Seyed Mohammad Fereshtehnejad9, Mostafa Qorbani10, Amir Radfar11, Maryam S Farvid12, Hamid Asayesh13, Sadaf G Sepanlou14, Shirin Djalalinia15, Amir Kasaeian16, Jagdish Khubchandani17, Reza Malekzadeh14, Maziar Moradi-Lakeh18, Kristopher J Krohn19, Ali H Mokdad19, Theo Vos19, Mohsen Naghavi19. 1. Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 2. Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA, Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA, Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health System, Denver, CO, USA. 3. Interdisciplinary Arts and Sciences, University of Washington, Tacoma, WA, USA. 4. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, I. R. of Iran. 5. Department of Urology, University of British Columbia, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada. 6. Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden. 7. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I. R. of Iran. 8. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, I. R. of Iran. 9. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. 10. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, I. R. of Iran. 11. College of Graduate Health Studies, A.T. Still University, Mesa, AZ, USA. 12. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 13. Department of Medical Emergencies, Qom University of Medical Sciecnes, Qom, I. R. of Iran. 14. Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, I. R. of Iran. 15. Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, I. R. of Iran, Non-communicable Diseases Research Center, EMRI, Tehran University of Medical Sciences, Tehran, I. R. of Iran. 16. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, I. R. of Iran. 17. Department of Nutrition and Health Science, Ball State University, Muncie, IN USA. 18. Community Medicine Specialist, Preventive Medicine and Public Health Research Center, Department of Community Medicine, Iran University of Medical Sciences, Tehran, I. R. of Iran. 19. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
Abstract
BACKGROUND: Iran and its neighboring countries represent four world regions with unique cultures and geography. Skin diseases span a wide diversity of etiologies including infectious, inflammatory, autoimmune, vascular, neurogenic, and oncologic. The Global Burden of Disease Study (GBD) 2015 measures the burden from skin diseases in 195 countries. METHODS: Epidemiologic data were collected from literature review, survey data, and hospital inpatient/outpatient claims data. These raw data entered modeling using a Bayesian meta-regression tool, DisMod MR-2.1, which yielded prevalence estimates by age/sex/location/year. Prevalence estimates were combined with disability weights to yield years lived with disability (YLDs). YLDs are combined with years of life lost (YLLs), from mortality estimates, to yield disability-adjusted life years (DALYs). DALYs were obtained for 16 skin conditions and both sexes in Iran and 15 surrounding countries. The sociodemographic index (SDI) for each country was also correlated with skin disease DALY rate using the Pearson coefficient (r) with two-tailed P-value. RESULTS: There was no significant correlation between individual skin diseases and SDI. Acne and dermatitis caused the greatest burden and BCC the lowest burden of skin diseases in Iran and the other 15 countries. SCC and BCC were responsible for the largest discrepancy by sex, with higher burden in males compared to females. CONCLUSION: Skin diseases, particularly dermatitis and acne, cause considerable burden in Iran and surrounding regions. Objective and transparent epidemiologic data such as GBD has the potential to inform and impact many facets of healthcare, research prioritization, public policy, and international partnerships.
BACKGROUND: Iran and its neighboring countries represent four world regions with unique cultures and geography. Skin diseases span a wide diversity of etiologies including infectious, inflammatory, autoimmune, vascular, neurogenic, and oncologic. The Global Burden of Disease Study (GBD) 2015 measures the burden from skin diseases in 195 countries. METHODS: Epidemiologic data were collected from literature review, survey data, and hospital inpatient/outpatient claims data. These raw data entered modeling using a Bayesian meta-regression tool, DisMod MR-2.1, which yielded prevalence estimates by age/sex/location/year. Prevalence estimates were combined with disability weights to yield years lived with disability (YLDs). YLDs are combined with years of life lost (YLLs), from mortality estimates, to yield disability-adjusted life years (DALYs). DALYs were obtained for 16 skin conditions and both sexes in Iran and 15 surrounding countries. The sociodemographic index (SDI) for each country was also correlated with skin disease DALY rate using the Pearson coefficient (r) with two-tailed P-value. RESULTS: There was no significant correlation between individual skin diseases and SDI. Acne and dermatitis caused the greatest burden and BCC the lowest burden of skin diseases in Iran and the other 15 countries. SCC and BCC were responsible for the largest discrepancy by sex, with higher burden in males compared to females. CONCLUSION:Skin diseases, particularly dermatitis and acne, cause considerable burden in Iran and surrounding regions. Objective and transparent epidemiologic data such as GBD has the potential to inform and impact many facets of healthcare, research prioritization, public policy, and international partnerships.