Literature DB >> 28745547

Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations.

Elodie Gautier-Veyret1,2,3, Sebastien Bailly2,3, Xavier Fonrose1, Julia Tonini1, Simon Chevalier1, Anne Thiebaut-Bertrand1,4, Françoise Stanke-Labesque1,2,3.   

Abstract

How pharmacogenetics modulates the inhibitory effects of inflammation on voriconazole trough concentration (Cmin) remains unknown. In 29 recipients of allogeneic hematopoietic stem cell transplantation retrospectively studied, both a genetic score (which aggregated CYP2C19 and CYP3A genotypes) and inflammation significantly influenced voriconazole Cmin (n = 260). A trend toward (p = 0.03) a greater impact of inflammation in patients with the highest genetic score (corresponding to ultra-rapid metabolizers) was observed. Further researches are needed to confirm these data.

Entities:  

Keywords:  CYP2C19; CYP3A4; inflammation; pharmacogenetics; therapeutic drug monitoring; voriconazole

Mesh：

Substances：

Year:  2017        PMID： 28745547     DOI： 10.2217/pgs-2017-0054

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  7 in total

Review 1.  Precision medicine: does ethnicity information complement genotype-based prescribing decisions?

Authors:  Rashmi R Shah; Andrea Gaedigk
Journal:  Ther Adv Drug Saf       Date:  2017-12-01

2.  Integrating anatomo-physiological changes and pharmacogenomics in anti-infective therapy management: is it a major concern?

Authors:  Laura Beaumier; Sébastien Chanoine; Elodie Gautier-Veyret; Hélène Pluchart; Muriel Cornet; Marie-Pierre Brenier-Pinchart; Xavier Fonrose; Boubou Camara; Pierrick Bedouch
Journal:  Br J Clin Pharmacol       Date:  2018-11-16       Impact factor: 4.335

3.  Applying Pharmacogenomics to Antifungal Selection and Dosing: Are We There Yet?

Authors:  Matthew A Miller; Yee Ming Lee
Journal:  Curr Fungal Infect Rep       Date:  2020-01-16

4.  Impact of polymorphisms of pharmacokinetics-related genes and the inflammatory response on the metabolism of voriconazole.

Authors:  Naoya Aiuchi; Junichi Nakagawa; Hirotake Sakuraba; Takenori Takahata; Kosuke Kamata; Norihiro Saito; Kayo Ueno; Masahiro Ishiyama; Kazufumi Yamagata; Hiroyuki Kayaba; Takenori Niioka
Journal:  Pharmacol Res Perspect       Date:  2022-04

5.  Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.

Authors:  Juan Chen; Ying Wu; Yuelin He; Xiaoqin Feng; Yuqiong Ren; Shiting Liu
Journal:  Front Pediatr       Date:  2022-03-21       Impact factor: 3.418

6.  Combined Impact of Inflammation and Pharmacogenomic Variants on Voriconazole Trough Concentrations: A Meta-Analysis of Individual Data.

Authors:  Léa Bolcato; Charles Khouri; Anette Veringa; Jan Willem C Alffenaar; Takahiro Yamada; Takafumi Naito; Fabien Lamoureux; Xavier Fonrose; Françoise Stanke-Labesque; Elodie Gautier-Veyret
Journal:  J Clin Med       Date:  2021-05-13       Impact factor: 4.241

Review 7.  Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment.

Authors:  Françoise Stanke-Labesque; Elodie Gautier-Veyret; Stephanie Chhun; Romain Guilhaumou
Journal:  Pharmacol Ther       Date:  2020-07-11       Impact factor: 12.310
  7 in total

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