| Literature DB >> 28745221 |
L Guilherme1,2, S Freschi de Barros1,2, K F Kohler1,2, S R Santos1,2, F Morais Ferreira1,2, W R Silva1,2, R Alencar1,2, E Postol1,2, J Kalil1,2,3.
Abstract
Rheumatic fever (RF) and rheumatic heart disease (RHD) follow untreated S. pyogenes throat infections in children who present susceptible genes that favor the development of autoimmune reactions. In this review, we focus on the genes that confer susceptibility and on the autoimmune reactions that occur due to molecular mimicry between human-tissue proteins and streptococcal M protein. Polyarthritis is the initial manifestation, which can evolve to carditis and severe valve damage; these culminate in rheumatic heart disease (RHD) or Sydenham's chorea, which affects the central nervous system. A perspective on vaccine development to prevent the disease is also discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: M protein; Rheumatic fever; T and B lymphocytes; anti-S. pyogenes vaccine; cytokines; genes; heart-tissue proteins; rheumatic heart disease.
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Year: 2018 PMID： 28745221 DOI： 10.2174/1389203718666170725115855
Source DB: PubMed Journal: Curr Protein Pept Sci ISSN： 1389-2037 Impact factor: 3.272