Literature DB >> 28741568

Genetic Redundancy, Functional Compensation, and Cancer Vulnerability.

Matteo Cereda1, Thanos P Mourikis1, Francesca D Ciccarelli2.   

Abstract

Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cancer genomics; functional redundancy; paralog dependency; personalized medicine; synthetic lethality

Mesh：

Year:  2016        PMID： 28741568     DOI： 10.1016/j.trecan.2016.03.003

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  8 in total

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6.  Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.

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  8 in total

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