Literature DB >> 28741527

Hypoxia: Signaling the Metastatic Cascade.

Erinn B Rankin1, Jin-Min Nam2, Amato J Giaccia3.   

Abstract

Hypoxia is a potent microenvironmental factor that promotes tumor metastasis. Recent studies have revealed mechanisms by which hypoxia and activation of hypoxia inducible factor (HIF)-dependent signaling promotes metastasis through the regulation of metabolic reprogramming, the stem cell phenotype, invasion, angiogenesis, immune suppression, the premetastatic niche, intravasation and/or extravasation, and resistance to apoptosis. These discoveries suggest novel paradigms in tumor metastasis and identify new opportunities for therapeutic intervention in the prevention and treatment of metastatic disease. Here, we review the impact of hypoxia and hypoxic signaling pathways in tumor and stromal cells on each step of the metastatic cascade.
Copyright © 2016. Published by Elsevier Inc.

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Mesh：

Year:  2016        PMID： 28741527      PMCID： PMC5808868          DOI： 10.1016/j.trecan.2016.05.006

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  90 in total

Review 1.  HIF transcription factors, inflammation, and immunity.

Authors:  Asis Palazon; Ananda W Goldrath; Victor Nizet; Randall S Johnson
Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

2.  Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

Authors:  Yanyan Lou; Lixia Diao; Edwin Roger Parra Cuentas; Warren L Denning; Limo Chen; You Hong Fan; Lauren A Byers; Jing Wang; Vassiliki A Papadimitrakopoulou; Carmen Behrens; Jaime Canales Rodriguez; Patrick Hwu; Ignacio I Wistuba; John V Heymach; Don L Gibbons
Journal:  Clin Cancer Res       Date:  2016-02-05       Impact factor: 12.531

3.  Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.

Authors:  Stephen M Hatfield; Jorgen Kjaergaard; Dmitriy Lukashev; Bryan Belikoff; Taylor H Schreiber; Shalini Sethumadhavan; Robert Abbott; Phaethon Philbrook; Molly Thayer; Dai Shujia; Scott Rodig; Jeffrey L Kutok; Jin Ren; Akio Ohta; Eckhard R Podack; Barry Karger; Edwin K Jackson; Michail Sitkovsky
Journal:  J Mol Med (Berl)       Date:  2014-08-15       Impact factor: 4.599

Review 4.  Metastatic stem cells: sources, niches, and vital pathways.

Authors:  Thordur Oskarsson; Eduard Batlle; Joan Massagué
Journal:  Cell Stem Cell       Date:  2014-03-06       Impact factor: 24.633

5.  Hypoxia inducible factor-1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study.

Authors:  Yoichiro Matsuo; Qiang Ding; Ryosuke Desaki; Kosei Maemura; Yuko Mataki; Hiroyuki Shinchi; Shoji Natsugoe; Sonshin Takao
Journal:  J Hepatobiliary Pancreat Sci       Date:  2013-06-20       Impact factor: 7.027

6.  Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.

Authors:  Keiyo Takubo; Nobuhito Goda; Wakako Yamada; Hirono Iriuchishima; Eiji Ikeda; Yoshiaki Kubota; Haruko Shima; Randall S Johnson; Atsushi Hirao; Makoto Suematsu; Toshio Suda
Journal:  Cell Stem Cell       Date:  2010-09-03       Impact factor: 24.633

7.  Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

Authors:  Toru Hiraga; Shinae Kizaka-Kondoh; Kiichi Hirota; Masahiro Hiraoka; Toshiyuki Yoneda
Journal:  Cancer Res       Date:  2007-05-01       Impact factor: 12.701

8.  Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells.

Authors:  Muhammad Zaeem Noman; Stéphanie Buart; Pedro Romero; Sami Ketari; Bassam Janji; Bernard Mari; Fathia Mami-Chouaib; Salem Chouaib
Journal:  Cancer Res       Date:  2012-09-07       Impact factor: 12.701

9.  Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.

Authors:  Joanna Baginska; Elodie Viry; Guy Berchem; Aurélie Poli; Muhammad Zaeem Noman; Kris van Moer; Sandrine Medves; Jacques Zimmer; Anaïs Oudin; Simone P Niclou; R Chris Bleackley; Ing Swie Goping; Salem Chouaib; Bassam Janji
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-07       Impact factor: 11.205

Review 10.  Hypoxia-inducible factors, stem cells, and cancer.

Authors:  Brian Keith; M Celeste Simon
Journal:  Cell       Date:  2007-05-04       Impact factor: 41.582
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  68 in total

1.  Electrochemical mapping of oxygenation in the three-dimensional multicellular tumour hemi-spheroid.

Authors:  Disha B Sheth; Miklόs Gratzl
Journal:  Proc Math Phys Eng Sci       Date:  2019-05-22       Impact factor: 2.704

2.  On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas.

Authors:  Anna A Brożyna; Wojciech Jóźwicki; Anton M Jetten; Andrzej T Slominski
Journal:  Exp Dermatol       Date:  2019-08-08       Impact factor: 3.960

Review 3.  The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies.

Authors:  Joaquín Araos; Jonathan P Sleeman; Boyan K Garvalov
Journal:  Clin Exp Metastasis       Date:  2018-08-31       Impact factor: 5.150

4.  Exosomes secreted by prostate cancer cells under hypoxia promote matrix metalloproteinases activity at pre-metastatic niches.

Authors:  Gagan Deep; Anil Jain; Ashish Kumar; Chapla Agarwal; Susy Kim; W Matthew Leevy; Rajesh Agarwal
Journal:  Mol Carcinog       Date:  2020-01-14       Impact factor: 4.784

Review 5.  Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia.

Authors:  Alexander I Kostyuk; Aleksandra D Kokova; Oleg V Podgorny; Ilya V Kelmanson; Elena S Fetisova; Vsevolod V Belousov; Dmitry S Bilan
Journal:  Antioxidants (Basel)       Date:  2020-06-11

6.  Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Authors:  Michael Skwarski; Daniel R McGowan; Elizabeth Belcher; Francesco Di Chiara; Dionisios Stavroulias; Mark McCole; Jennifer L Derham; Kwun-Ye Chu; Eugene Teoh; Jagat Chauhan; Dawn O'Reilly; Benjamin H L Harris; Philip S Macklin; Joshua A Bull; Marcus Green; Gonzalo Rodriguez-Berriguete; Remko Prevo; Lisa K Folkes; Leticia Campo; Petra Ferencz; Paula L Croal; Helen Flight; Cathy Qi; Jane Holmes; James P B O'Connor; Fergus V Gleeson; W Gillies McKenna; Adrian L Harris; Daniel Bulte; Francesca M Buffa; Ruth E Macpherson; Geoff S Higgins
Journal:  Clin Cancer Res       Date:  2021-02-17       Impact factor: 12.531

Review 7.  Biophysical characterization of melanoma cell phenotype markers during metastatic progression.

Authors:  Anna Sobiepanek; Alessio Paone; Francesca Cutruzzolà; Tomasz Kobiela
Journal:  Eur Biophys J       Date:  2021-03-17       Impact factor: 1.733

8.  Immunotherapy Using Oxygenated Water and Tumor-Derived Exosomes Potentiates Antitumor Immune Response and Attenuates Malignancy Tendency in Mice Model of Breast Cancer.

Authors:  Nafiseh Pakravan; Ardeshir Abbasi; Zuhair Mohammad Hassan
Journal:  Oxid Med Cell Longev       Date:  2021-05-28       Impact factor: 6.543

9.  Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia.

Authors:  Duo You; Danfeng Du; Xueke Zhao; Xinmin Li; Minfeng Ying; Xun Hu
Journal:  Chin J Cancer Res       Date:  2021-06-30       Impact factor: 5.087

Review 10.  Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States.

Authors:  Laura Bornes; Guillaume Belthier; Jacco van Rheenen
Journal:  J Clin Med       Date:  2021-05-29       Impact factor: 4.241
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