Literature DB >> 28741354

Stereocontrolled Synthesis of Left Halves of Halichondrins.

Kenzo Yahata1, Ning Ye1, Kentaro Iso1, Yanran Ai1, Jihoon Lee1, Yoshito Kishi1.   

Abstract

A stereocontrolled synthesis of the left halves of halichondrins was reported. An intramolecular oxy-Michael reaction under basic conditions was used to construct the [6,6]-spiroketal in a stereocontrolled manner. With this approach, the left halves of halichondrins, homohalichondrins, and norhalichondrins were synthesized.

Entities:  

Year:  2017        PMID： 28741354     DOI： 10.1021/acs.joc.7b01284

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  First total syntheses of the pro-resolving lipid mediators 7(S),13(R),20(S)-Resolvin T1 and 7(S),13(R)-Resolvin T4.

Authors:  Ana R Rodriguez; Bernd W Spur
Journal:  Tetrahedron Lett       Date:  2019-12-05       Impact factor: 2.415

2.  Total Synthesis of the Marine Phosphomacrolide, (-)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis-Ferrier Union/Rearrangement.

Authors:  Yanran Ai; Mariya V Kozytska; Yike Zou; Anton S Khartulyari; William A Maio; Amos B Smith
Journal:  J Org Chem       Date:  2018-05-22       Impact factor: 4.354
  2 in total

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