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Literature DB >> 28741120

CADASIL: Treatment and Management Options.

Anna Bersano¹, Gloria Bedini², Joshua Oskam³, Caterina Mariotti⁴, Franco Taroni⁴, Silvia Baratta⁴, Eugenio Agostino Parati⁵.

Abstract

OPINION STATEMENT: CADASIL is a life-threatening and disabling disease. Despite the progress achieved so far, no therapies able to limit the disease progression have been found and only empiric treatments can be employed to relieve the main disease symptoms. Further in vivo studies as well as data aggregation and multi-centre controlled clinical trials are needed to confirm the emerging findings in order to identify evidence-based therapies for CADASIL.

Keywords: CADASIL; NOTCH3 gene; Pathogenesis; Therapy

Year: 2017 PMID： 28741120 DOI： 10.1007/s11940-017-0468-z

Source DB: PubMed Journal: Curr Treat Options Neurol ISSN： 1092-8480 Impact factor: 3.598

105 in total

1. Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study.

Authors: Markus Holtmannspötter; Nils Peters; Christian Opherk; Daniel Martin; Jürgen Herzog; Hartmut Brückmann; Philipp Sämann; Andreas Gschwendtner; Martin Dichgans
Journal: Stroke Date: 2005-11-03 Impact factor: 7.914

2. Motor cortex cholinergic dysfunction in CADASIL: a transcranial magnetic demonstration.

Authors: Fiore Manganelli; Michele Ragno; Gabriella Cacchiò; Valeria Iodice; Luigi Trojano; Flavia Silvaggio; Maria Scarcella; Michela Grazioli; Lucio Santoro; Anna Perretti
Journal: Clin Neurophysiol Date: 2007-12-11 Impact factor: 3.708

3. Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL.

Authors: Akira Ishiko; Atsushi Shimizu; Eiichiro Nagata; Keikichi Takahashi; Takeshi Tabira; Norihiro Suzuki
Journal: Acta Neuropathol Date: 2006-07-27 Impact factor: 17.088

Review 4. Therapeutic strategies in migraine patients with mood and anxiety disorders: clinical evidence.

Authors: Cinzia Finocchi; Veronica Villani; Gerardo Casucci
Journal: Neurol Sci Date: 2010-06 Impact factor: 3.307

5. Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study.

Authors: Hugues Chabriat; Dominique Hervé; Marco Duering; Ophelia Godin; Eric Jouvent; Christian Opherk; Nassira Alili; Sonia Reyes; Aude Jabouley; Nikola Zieren; Jean-Pierre Guichard; Chahin Pachai; Eric Vicaut; Martin Dichgans
Journal: Stroke Date: 2015-11-17 Impact factor: 7.914

6. Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL.

Authors: Nils Peters; Tobias Freilinger; Christian Opherk; Thomas Pfefferkorn; Martin Dichgans
Journal: J Neurol Sci Date: 2007-05-24 Impact factor: 3.181

7. A two-year clinical follow-up study in 80 CADASIL subjects: progression patterns and implications for clinical trials.

Authors: Nils Peters; Jürgen Herzog; Christian Opherk; Martin Dichgans
Journal: Stroke Date: 2004-05-20 Impact factor: 7.914

8. Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Authors: H Chabriat; K Vahedi; M T Iba-Zizen; A Joutel; A Nibbio; T G Nagy; M O Krebs; J Julien; B Dubois; X Ducrocq
Journal: Lancet Date: 1995-10-07 Impact factor: 79.321

9. Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience.

Authors: Ida Donnini; Serena Nannucci; Raffaella Valenti; Francesca Pescini; Silvia Bianchi; Domenico Inzitari; Leonardo Pantoni
Journal: J Headache Pain Date: 2012-02-25 Impact factor: 7.277

10. Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals.

Authors: Robert Clarke; Derrick Bennett; Sarah Parish; Sarah Lewington; Murray Skeaff; Simone J P M Eussen; Catharina Lewerin; David J Stott; Jane Armitage; Graeme J Hankey; Eva Lonn; J David Spence; Pilar Galan; Lisette C de Groot; Jim Halsey; Alan D Dangour; Rory Collins; Francine Grodstein
Journal: Am J Clin Nutr Date: 2014-06-25 Impact factor: 7.045

9 in total

1. Identification of a novel NOTCH3 mutation in an Italian family affected by a mild form of CADASIL.

Authors: Enrico Ferrante; Lorena Mosca; Cristina Erminio; Silvana Penco; Ugo Cavallari
Journal: Neurol Sci Date: 2019-03-01 Impact factor: 3.307

Review 2. Nucleic Acid Therapies for Ischemic Stroke.

Authors: Nils Henninger; Yunis Mayasi
Journal: Neurotherapeutics Date: 2019-04 Impact factor: 7.620

Review 3. Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.

Authors: Dorothee Schoemaker; Joseph F Arboleda-Velasquez
Journal: Am J Pathol Date: 2021-04-22 Impact factor: 4.307

4. Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions.

Authors: Takashi Okada; Kazuo Washida; Kenichi Irie; Satoshi Saito; Michio Noguchi; Tsutomu Tomita; Masatoshi Koga; Kazunori Toyoda; Shuhei Okazaki; Takashi Koizumi; Ikuko Mizuta; Toshiki Mizuno; Masafumi Ihara
Journal: Front Aging Neurosci Date: 2020-05-14 Impact factor: 5.750