Praneel Kumar1, Stephanie Law1, Krishna B Sriram1,2. 1. School of Medicine, Parklands Drive, Griffith University, Southport, Queensland 4215, Australia. 2. Department of Respiratory Medicine, Gold Coast University Hospital, Southport, Queensland 4215, Australia.
Abstract
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have high mortality and health care costs. The platelet to lymphocyte ratio (PLR) is a marker of inflammation and has been reported to be elevated in patients with AECOPD compared to stable state. In this study, we sought to evaluate the association of the PLR in patients with AECOPD with 90-day mortality. METHODS: We conducted a retrospective cohort study of patients admitted to our institution with a primary diagnosis of AECOPD between January 2014 and July 2014. Blood test results on admission were recorded. The primary outcomes were 90-day mortality. RESULTS: One hundred and eighty-one AECOPD patients were considered for the study. Death had occurred in 16 (9%) patients within 90 days of hospital discharge. Univariable analysis identified age, haemoglobin, neutrophil count, and urea level, neutrophil lymphocyte ratio (NLR) and PLR as being associated with increased 90-day mortality. Multivariable logistic regression analysis variables demonstrated that only PLR (P=0.03) was significantly associated with death at 90 days. Receiver operator characteristic analysis identified PLR ≥235 had a sensitivity of 63% and specificity of 74% in predicting 90-day mortality. PLR was ≥235 was also associated with worse survival (days) [mean ± standard deviation (SD): PLR ≥235 vs. PLR <235: 512±358 vs. 626±346, P=0.004]. CONCLUSIONS: A PLR ≥235 was significantly associated with 90-day mortality, which may provide prognostic guidance to clinicians.
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have high mortality and health care costs. The platelet to lymphocyte ratio (PLR) is a marker of inflammation and has been reported to be elevated in patients with AECOPD compared to stable state. In this study, we sought to evaluate the association of the PLR in patients with AECOPD with 90-day mortality. METHODS: We conducted a retrospective cohort study of patients admitted to our institution with a primary diagnosis of AECOPD between January 2014 and July 2014. Blood test results on admission were recorded. The primary outcomes were 90-day mortality. RESULTS: One hundred and eighty-one AECOPDpatients were considered for the study. Death had occurred in 16 (9%) patients within 90 days of hospital discharge. Univariable analysis identified age, haemoglobin, neutrophil count, and urea level, neutrophil lymphocyte ratio (NLR) and PLR as being associated with increased 90-day mortality. Multivariable logistic regression analysis variables demonstrated that only PLR (P=0.03) was significantly associated with death at 90 days. Receiver operator characteristic analysis identified PLR ≥235 had a sensitivity of 63% and specificity of 74% in predicting 90-day mortality. PLR was ≥235 was also associated with worse survival (days) [mean ± standard deviation (SD): PLR ≥235 vs. PLR <235: 512±358 vs. 626±346, P=0.004]. CONCLUSIONS: A PLR ≥235 was significantly associated with 90-day mortality, which may provide prognostic guidance to clinicians.
Authors: Arnoud J Templeton; Olga Ace; Mairéad G McNamara; Mustafa Al-Mubarak; Francisco E Vera-Badillo; Thomas Hermanns; Boštjan Seruga; Alberto Ocaña; Ian F Tannock; Eitan Amir Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-05-03 Impact factor: 4.254
Authors: Michelle T Harrison; Philip Short; Peter A Williamson; Aran Singanayagam; James D Chalmers; Stuart Schembri Journal: Thorax Date: 2014-04-17 Impact factor: 9.139
Authors: Mette Thomsen; Morten Dahl; Peter Lange; Jørgen Vestbo; Børge G Nordestgaard Journal: Am J Respir Crit Care Med Date: 2012-09-13 Impact factor: 21.405
Authors: Robert E Walter; Jemma B Wilk; Martin G Larson; Ramachandran S Vasan; John F Keaney; Izabella Lipinska; George T O'Connor; Emelia J Benjamin Journal: Chest Date: 2007-10-01 Impact factor: 9.410
Authors: Bartolome R Celli; Nicholas Locantore; Julie Yates; Ruth Tal-Singer; Bruce E Miller; Per Bakke; Peter Calverley; Harvey Coxson; Courtney Crim; Lisa D Edwards; David A Lomas; Annelyse Duvoix; William MacNee; Stephen Rennard; Edwin Silverman; Jørgen Vestbo; Emiel Wouters; Alvar Agustí Journal: Am J Respir Crit Care Med Date: 2012-03-15 Impact factor: 21.405
Authors: Angelo Zinellu; Elisabetta Zinellu; Maria Carmina Pau; Ciriaco Carru; Pietro Pirina; Alessandro G Fois; Arduino A Mangoni Journal: J Clin Med Date: 2022-06-11 Impact factor: 4.964