| Literature DB >> 28740584 |
Morali D Sharma1, Anh V Nguyen1, Spandana Brown1, Richard J Robbins1.
Abstract
In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.Entities:
Keywords: acromegaly; arrhythmia; cardiomyopathy; coronary artery disease; heart failure; hypertension; valvular heart disease
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Year: 2017 PMID: 28740584 PMCID: PMC5512681 DOI: 10.14797/mdcj-13-2-64
Source DB: PubMed Journal: Methodist Debakey Cardiovasc J ISSN: 1947-6108