Literature DB >> 2874022

Two regulatory fim genes, fimB and fimE, control the phase variation of type 1 fimbriae in Escherichia coli.

P Klemm.   

Abstract

The expression of type 1 fimbriae in Escherichia coli is phase dependent, i.e. a cell is either completely fimbriated or bald. This phenomenon is due to the periodic inversion of a specific 300-bp DNA segment containing the promoter for the fimbrial subunit gene, fimA. The phase switch is controlled by the products of two regulatory genes, fimB and fimE, located upstream of fimA. The fimB and fimE proteins direct the phase switch into the 'on' and 'off' position, respectively. The DNA sequence of a 3000-bp region containing the two genes has been determined. The fimB and fimE proteins exhibit strong homology and have most likely originated by duplication of an ancestral gene. They are highly basic implying that they control the phase switch through interaction at the DNA level.

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Year:  1986        PMID： 2874022      PMCID： PMC1166953          DOI： 10.1002/j.1460-2075.1986.tb04372.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  20 in total

1.  MINIATURE escherichia coli CELLS DEFICIENT IN DNA.

Authors:  H I Adler; W D Fisher; A Cohen; A A Hardigree
Journal:  Proc Natl Acad Sci U S A       Date:  1967-02       Impact factor: 11.205

2.  A complementation analysis of the restriction and modification of DNA in Escherichia coli.

Authors:  H W Boyer; D Roulland-Dussoix
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

3.  Two modes of control of pilA, the gene encoding type 1 pilin in Escherichia coli.

Authors:  P E Orndorff; P A Spears; D Schauer; S Falkow
Journal:  J Bacteriol       Date:  1985-10       Impact factor: 3.490

4.  Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control.

Authors:  B I Eisenstein
Journal:  Science       Date:  1981-10-16       Impact factor: 47.728

5.  flu, a metastable gene controlling surface properties of Escherichia coli.

Authors:  B Diderichsen
Journal:  J Bacteriol       Date:  1980-02       Impact factor: 3.490

6.  Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.

Authors:  M J Casadaban; S N Cohen
Journal:  J Mol Biol       Date:  1980-04       Impact factor: 5.469

Review 7.  Fimbrial adhesions of Escherichia coli.

Authors:  P Klemm
Journal:  Rev Infect Dis       Date:  1985 May-Jun

8.  The fimA gene encoding the type-1 fimbrial subunit of Escherichia coli. Nucleotide sequence and primary structure of the protein.

Authors:  P Klemm
Journal:  Eur J Biochem       Date:  1984-09-03

9.  Identification and characterization of a gene product that regulates type 1 piliation in Escherichia coli.

Authors:  P E Orndorff; S Falkow
Journal:  J Bacteriol       Date:  1984-10       Impact factor: 3.490

10.  Genetic analysis of the phase variation control of expression of type 1 fimbriae in Escherichia coli.

Authors:  C S Freitag; J M Abraham; J R Clements; B I Eisenstein
Journal:  J Bacteriol       Date:  1985-05       Impact factor: 3.490
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  158 in total

Review 1.  Molecular basis of the interaction of Salmonella with the intestinal mucosa.

Authors:  K H Darwin; V L Miller
Journal:  Clin Microbiol Rev       Date:  1999-07       Impact factor: 26.132

2.  Type 1 fimbriation and phase switching in a natural Escherichia coli fimB null strain, Nissle 1917.

Authors:  B Stentebjerg-Olesen; T Chakraborty; P Klemm
Journal:  J Bacteriol       Date:  1999-12       Impact factor: 3.490

3.  Interaction of the FimB integrase with the fimS invertible DNA element in Escherichia coli in vivo and in vitro.

Authors:  L S Burns; S G Smith; C J Dorman
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

4.  Antigen 43 and type 1 fimbriae determine colony morphology of Escherichia coli K-12.

Authors:  H Hasman; M A Schembri; P Klemm
Journal:  J Bacteriol       Date:  2000-02       Impact factor: 3.490

5.  Osmolarity and pH growth conditions regulate fim gene transcription and type 1 pilus expression in uropathogenic Escherichia coli.

Authors:  William R Schwan; Jeffrey L Lee; Farrah A Lenard; Brian T Matthews; Michael T Beck
Journal:  Infect Immun       Date:  2002-03       Impact factor: 3.441

6.  Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Authors:  Maria Kostakioti; Maria Hadjifrangiskou; Corinne K Cusumano; Thomas J Hannan; James W Janetka; Scott J Hultgren
Journal:  Infect Immun       Date:  2012-06-04       Impact factor: 3.441

7.  Decreased expression of type 1 fimbriae by a pst mutant of uropathogenic Escherichia coli reduces urinary tract infection.

Authors:  Sébastien Crépin; Sébastien Houle; Marie-Ève Charbonneau; Michaël Mourez; Josée Harel; Charles M Dozois
Journal:  Infect Immun       Date:  2012-06-04       Impact factor: 3.441

Review 8.  Phase and antigenic variation in bacteria.

Authors:  Marjan W van der Woude; Andreas J Bäumler
Journal:  Clin Microbiol Rev       Date:  2004-07       Impact factor: 26.132

9.  IscR controls iron-dependent biofilm formation in Escherichia coli by regulating type I fimbria expression.

Authors:  Yun Wu; F Wayne Outten
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490

Review 10.  The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.

Authors:  J M Calvo; R G Matthews
Journal:  Microbiol Rev       Date:  1994-09
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