| Literature DB >> 28739976 |
Louise V Wain1, Ahmad Vaez2,3, Rick Jansen4, Roby Joehanes5,6, Peter J van der Most7, A Mesut Erzurumluoglu1, Paul F O'Reilly8, Claudia P Cabrera9,10, Helen R Warren9,10, Lynda M Rose11, Germaine C Verwoert12, Jouke-Jan Hottenga13, Rona J Strawbridge14,15, Tonu Esko16,17,18, Dan E Arking19, Shih-Jen Hwang20,21, Xiuqing Guo22, Zoltan Kutalik23,24, Stella Trompet25, Nick Shrine1, Alexander Teumer26,27, Janina S Ried28, Joshua C Bis29, Albert V Smith30,31, Najaf Amin32, Ilja M Nolte2, Leo-Pekka Lyytikäinen33,34, Anubha Mahajan35, Nicholas J Wareham36, Edith Hofer37,38, Peter K Joshi39, Kati Kristiansson40, Michela Traglia41, Aki S Havulinna40, Anuj Goel42, Mike A Nalls43,44, Siim Sõber45, Dragana Vuckovic46,47, Jian'an Luan36, Fabiola Del Greco M48, Kristin L Ayers49, Jaume Marrugat50, Daniela Ruggiero51, Lorna M Lopez52,53,54, Teemu Niiranen40, Stefan Enroth55, Anne U Jackson56, Christopher P Nelson7,57, Jennifer E Huffman58, Weihua Zhang59,60, Jonathan Marten58, Ilaria Gandin47, Sarah E Harris52,61, Tatijana Zemunik62, Yingchang Lu63, Evangelos Evangelou59,64, Nabi Shah65,66, Martin H de Borst67, Massimo Mangino68,69, Bram P Prins70, Archie Campbell71,72, Ruifang Li-Gao73, Ganesh Chauhan74,75, Christopher Oldmeadow76, Gonçalo Abecasis77, Maryam Abedi78, Caterina M Barbieri41, Michael R Barnes9,10, Chiara Batini1, John Beilby79,80,81, Tineka Blake1, Michael Boehnke56, Erwin P Bottinger63, Peter S Braund7,57, Morris Brown9,10, Marco Brumat47, Harry Campbell39, John C Chambers59,60,82, Massimiliano Cocca47, Francis Collins83, John Connell84, Heather J Cordell85, Jeffrey J Damman11, Gail Davies52,86, Eco J de Geus13, Renée de Mutsert73, Joris Deelen87, Yusuf Demirkale88, Alex S F Doney65, Marcus Dörr89,27, Martin Farrall35,42, Teresa Ferreira35, Mattias Frånberg14,15,90, He Gao59, Vilmantas Giedraitis91, Christian Gieger92, Franco Giulianini11, Alan J Gow52,93, Anders Hamsten14,15, Tamara B Harris94, Albert Hofman12,95, Elizabeth G Holliday76, Jennie Hui79,80,81,96, Marjo-Riitta Jarvelin97,98,99,100, Åsa Johansson55, Andrew D Johnson6,101, Pekka Jousilahti40, Antti Jula40, Mika Kähönen102,103, Sekar Kathiresan104,105,106, Kay-Tee Khaw107, Ivana Kolcic108, Seppo Koskinen40, Claudia Langenberg36, Marty Larson6, Lenore J Launer94, Benjamin Lehne59, David C M Liewald52,86, Li Lin109, Lars Lind110, François Mach109, Chrysovalanto Mamasoula111, Cristina Menni68, Borbala Mifsud9, Yuri Milaneschi112, Anna Morgan47, Andrew D Morris113, Alanna C Morrison114, Peter J Munson88, Priyanka Nandakumar19, Quang Tri Nguyen83, Teresa Nutile51, Albertine J Oldehinkel115, Ben A Oostra32, Elin Org16, Sandosh Padmanabhan72,116, Aarno Palotie117, Guillaume Paré118, Alison Pattie86, Brenda W J H Penninx112, Neil Poulter119, Peter P Pramstaller48,120,121, Olli T Raitakari122,123, Meixia Ren9,124, Kenneth Rice125, Paul M Ridker11,126, Harriëtte Riese115, Samuli Ripatti117, Antonietta Robino127, Jerome I Rotter128, Igor Rudan39, Yasaman Saba129, Aude Saint Pierre48, Cinzia F Sala41, Antti-Pekka Sarin117, Reinhold Schmidt37, Rodney Scott76,130,131, Marc A Seelen67, Denis C Shields132, David Siscovick133, Rossella Sorice51,134, Alice Stanton135, David J Stott136, Johan Sundström110, Morris Swertz137, Kent D Taylor138,139, Simon Thom140, Ioanna Tzoulaki59, Christophe Tzourio74,75,141, André G Uitterlinden12,142, Uwe Völker143,27, Peter Vollenweider144, Sarah Wild39, Gonneke Willemsen13, Alan F Wright58, Jie Yao22, Sébastien Thériault118, David Conen145, John Attia76,130,131, Peter Sever146, Stéphanie Debette74,75,147, Dennis O Mook-Kanamori73,148, Eleftheria Zeggini70, Tim D Spector68, Pim van der Harst149, Colin N A Palmer65, Anne-Claire Vergnaud59, Ruth J F Loos36,63,150, Ozren Polasek108, John M Starr52,151, Giorgia Girotto46,47, Caroline Hayward72,152, Jaspal S Kooner60,82,153, Cecila M Lindgren18,35, Veronique Vitart58, Nilesh J Samani7,57, Jaakko Tuomilehto154,155,156,157,158, Ulf Gyllensten55, Paul Knekt40, Ian J Deary52,86, Marina Ciullo51,134, Roberto Elosua50, Bernard D Keavney159, Andrew A Hicks48, Robert A Scott36, Paolo Gasparini46,47, Maris Laan45, YongMei Liu160, Hugh Watkins35,42, Catharina A Hartman115, Veikko Salomaa40, Daniela Toniolo41, Markus Perola161,40,117, James F Wilson39,58, Helena Schmidt162,129, Jing Hua Zhao36, Terho Lehtimäki33,34, Cornelia M van Duijn32, Vilmundur Gudnason30,31, Bruce M Psaty29,163,164,165, Annette Peters28, Rainer Rettig166, Alan James167,168, J Wouter Jukema25, David P Strachan169, Walter Palmas170, Andres Metspalu16, Erik Ingelsson171,172, Dorret I Boomsma13, Oscar H Franco12, Murielle Bochud23, Christopher Newton-Cheh18,104,173,106, Patricia B Munroe9,10, Paul Elliott97, Daniel I Chasman11,126, Aravinda Chakravarti19, Joanne Knight174, Andrew P Morris35,175, Daniel Levy20,21, Martin D Tobin1, Harold Snieder2, Mark J Caulfield9,10, Georg B Ehret19,109.
Abstract
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.Entities:
Keywords: GWAS; blood pressure; cardiovascular risk; complex traits; eSNP; hypertension
Year: 2017 PMID： 28739976 PMCID： PMC5783787 DOI： 10.1161/HYPERTENSIONAHA.117.09438
Source DB: PubMed Journal: Hypertension ISSN： 0194-911X Impact factor: 9.897