Liyan Liu1, Huishan Zhao2, Lin Sheng2, Ping Yang2, Huihui Zhou3, Ruizheng Wang4. 1. The Fifth People's Hospital of Ji'nan, Jinan, P.R. China. 2. Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China. 3. Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China yhdyypathology@163.com 18954577787@163.com. 4. The Fifth People's Hospital of Ji'nan, Jinan, P.R. China yhdyypathology@163.com 18954577787@163.com.
Abstract
BACKGROUND/AIM: Collision of Epstein-Barr virus (EBV)-associated lymphoepithelioma-like carcinoma (LELC) with non-Hodgkin's lymphoma of the stomach is extremely rare. PATIENTS AND METHODS: Herein we report a case of LELC with primary diffuse large B-cell lymphoma (DLBCL) of the stomach in a 65-year-old patient. RESULTS: Gastric endoscopy showed a poorly differentiated adenocarcinoma of the stomach. The patient underwent radical gastrectomy, and histopathological examinations revealed the collision of LELC and DLBCL of the stomach. In situ hybridization showed that most carcinoma cells of LELC were positive for EBV-encoded small RNA (EBER) suggesting that the virus infection happened in the early stage of tumorigenesis, while DLBCL was negative. CONCLUSION: This is the first report of collision of EBV-associated LELC with primary DLBCL of the stomach. Copyright
BACKGROUND/AIM: Collision of Epstein-Barr virus (EBV)-associated lymphoepithelioma-like carcinoma (LELC) with non-Hodgkin's lymphoma of the stomach is extremely rare. PATIENTS AND METHODS: Herein we report a case of LELC with primary diffuse large B-cell lymphoma (DLBCL) of the stomach in a 65-year-old patient. RESULTS: Gastric endoscopy showed a poorly differentiated adenocarcinoma of the stomach. The patient underwent radical gastrectomy, and histopathological examinations revealed the collision of LELC and DLBCL of the stomach. In situ hybridization showed that most carcinoma cells of LELC were positive for EBV-encoded small RNA (EBER) suggesting that the virus infection happened in the early stage of tumorigenesis, while DLBCL was negative. CONCLUSION: This is the first report of collision of EBV-associated LELC with primary DLBCL of the stomach. Copyright