Oleksandra Klapko1, Elie Ghoulam2, Shriram Jakate3, Sheila Eswaran2, Lydia Usha4. 1. Division of Hematology/Oncology and Stem Cell Transplant, Rush University Medical Center, Chicago, IL, U.S.A. 2. Section of Hepatology, Department of Medicine, Rush University Medical Center, Chicago, IL, U.S.A. 3. Department of Pathology, Rush University Medical Center, Chicago, IL, U.S.A. 4. Division of Hematology/Oncology and Stem Cell Transplant, Rush University Medical Center, Chicago, IL, U.S.A. lydia_usha@rush.edu.
Abstract
BACKGROUND: Autoimmune hepatitis (AIH) is an extremely rare complication of anastrozole therapy. It presents with elevated liver function tests. The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. It is confirmed with a liver biopsy showing interface rosetting and an increased number of plasma cells. Early diagnosis of anastrozole-induced AIH is important because it allows anastrozole to be discontinued and immunomodulatory treatment to be promptly initiated. CASE REPORT: We present the case of a 71-year-old female patient diagnosed with early-stage breast cancer. The patient developed AIH as a result of treatment with anastrozole. Its clinicopathological presentation, diagnosis, and treatment are reviewed. CONCLUSION: This case report intends to make clinicians aware of this rare complication of anastrozole therapy. AIH should be suspected in any patient on anastrozole (and possibly, other aromatase inhibitors) who develops elevated liver function tests. Copyright
BACKGROUND:Autoimmune hepatitis (AIH) is an extremely rare complication of anastrozole therapy. It presents with elevated liver function tests. The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. It is confirmed with a liver biopsy showing interface rosetting and an increased number of plasma cells. Early diagnosis of anastrozole-induced AIH is important because it allows anastrozole to be discontinued and immunomodulatory treatment to be promptly initiated. CASE REPORT: We present the case of a 71-year-old female patient diagnosed with early-stage breast cancer. The patient developed AIH as a result of treatment with anastrozole. Its clinicopathological presentation, diagnosis, and treatment are reviewed. CONCLUSION: This case report intends to make clinicians aware of this rare complication of anastrozole therapy. AIH should be suspected in any patient on anastrozole (and possibly, other aromatase inhibitors) who develops elevated liver function tests. Copyright
Authors: Ana Ezponda; Ignacio González De La Huebra; Marta Calvo; Miguel Ángel Idoate; Isabel Vivas Journal: Oncol Lett Date: 2018-07-10 Impact factor: 2.967