Saud Alzahrani1, Jason Nelson2, Steven F Moss3, Jessica K Paulus2, William C Knowler4, Anastassios G Pittas5. 1. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: dr_alzahrani_s@yahoo.com. 2. Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA. 3. Division of Gastroenterology, Brown University, Providence, RI. 4. National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ. 5. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Abstract
OBJECTIVE: To determine the association between H. pylori infection and risk of incident diabetes in adults at high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study. METHODS: In a nested case-control study conducted among 421 adults with newly diagnosed diabetes and 421 matched controls, we examined the association between serological status of H. pylori at baseline and risk of incident diabetes over a mean follow-up period of 2.6years. Using data from the baseline visit of the DPP, we also examined the cross-sectional association between presence of H. pylori antibodies and insulin sensitivity, insulin secretion and the disposition index-like measure after a 75-g oral glucose tolerance test (OGTT). RESULTS: At baseline, H. pylori antibodies were present in 40% of participants who developed diabetes and 39% of controls. After adjusting for matching factors, there was no association between exposure to H. pylori and incident diabetes (odds ratio [OR] of 1.04 (95% CI, 0.77 to 1.40). In cross-sectional analyses, H. pylori status was not significantly associated with insulin sensitivity and disposition index-like measure from OGTT. CONCLUSIONS: In adults at high risk for diabetes, H. pylori seropositivity was not associated with risk of developing diabetes.
OBJECTIVE: To determine the association between H. pyloriinfection and risk of incident diabetes in adults at high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study. METHODS: In a nested case-control study conducted among 421 adults with newly diagnosed diabetes and 421 matched controls, we examined the association between serological status of H. pylori at baseline and risk of incident diabetes over a mean follow-up period of 2.6years. Using data from the baseline visit of the DPP, we also examined the cross-sectional association between presence of H. pylori antibodies and insulin sensitivity, insulin secretion and the disposition index-like measure after a 75-g oral glucose tolerance test (OGTT). RESULTS: At baseline, H. pylori antibodies were present in 40% of participants who developed diabetes and 39% of controls. After adjusting for matching factors, there was no association between exposure to H. pylori and incident diabetes (odds ratio [OR] of 1.04 (95% CI, 0.77 to 1.40). In cross-sectional analyses, H. pylori status was not significantly associated with insulin sensitivity and disposition index-like measure from OGTT. CONCLUSIONS: In adults at high risk for diabetes, H. pylori seropositivity was not associated with risk of developing diabetes.
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