Literature DB >> 28739252

Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons.

Bartlomiej Szulczyk1, Ewa Nurowska2.   

Abstract

Valproic acid is frequently prescribed and used to treat epilepsy, bipolar disorder and other conditions. However, the mechanism of action of valproic acid has not been fully elucidated. The aim of this study was to assess the influence of valproic acid (200 μM) on TTX-resistant sodium currents in mPFC pyramidal neurons. Valproic acid inhibited the maximal amplitude and did not change the activation parameters of TTX-resistant sodium currents. Moreover, valproic acid (2 μM and 200 μM) shifted the TTX-resistant sodium channel inactivation curve towards hyperpolarisation. In the presence of valproic acid, TTX-resistant sodium currents recovered from inactivation more slowly. Valproic acid did not influence the use-dependent blockade of TTX-resistant sodium currents. This study suggests that a potential new mechanism of the antiepileptic action of valproic acid is, among others, inhibition of TTX-resistant sodium currents.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Epilepsia; Patch-clamp; Prefrontal cortex; TTX-resistant sodium current; Valproic acid

Mesh：

Substances：

Year:  2017        PMID： 28739252     DOI： 10.1016/j.bbrc.2017.07.109

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

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Journal:  Neurotherapeutics       Date:  2020-01       Impact factor: 7.620

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Authors:  Michał Abram; Marcin Jakubiec; Anna Rapacz; Szczepan Mogilski; Gniewomir Latacz; Bartłomiej Szulczyk; Małgorzata Szafarz; Katarzyna Socała; Dorota Nieoczym; Elżbieta Wyska; Piotr Wlaź; Rafał M Kamiński; Krzysztof Kamiński
Journal:  Int J Mol Sci       Date:  2021-12-03       Impact factor: 5.923
  4 in total

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