| Literature DB >> 2873866 |
S Yamada, Y Kagawa, N Takayanagi, E Hayashi, K Tsuji, T Kosuge.
Abstract
We have found a selective inhibition of nicotine-induced antinociception in mice by neosurugatoxin (NSTX, 0.4-3.8 nmol/kg), a neurotoxin with a high affinity for ganglionic nicotinic receptors (ED50 = 0.65 nmol/kg). The toxin also reduced specific [3H]nicotine binding in mouse brain membranes (IC50 = 95 nM). The anti-nicotinic activity of NSTX was markedly greater than that of mecamylamine and pempidine. These data indicate that NSTX may block functional nicotinic cholinoceptors possibly in the central nervous system.Entities:
Mesh：
Substances：
Year: 1986 PMID： 2873866 DOI： 10.1016/0006-8993(86)90758-4
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252