Literature DB >> 28737764

Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis.

Jin Gong1, Jian Han1, Jiayi He2, Jingmei Liu1, Ping Han1, Yunwu Wang1, Mengke Li1, Dongxiao Li1, Xiangming Ding1, Zhipeng Du1, Jiazhi Liao1, Dean Tian1.   

Abstract

Activation of the platelet-derived growth factor (PDGF)/PDGF beta receptor (PDGFβR) axis has a critical role in liver fibrosis. However, the mechanisms that regulate the PDGF signaling are yet to be elucidated. The present study demonstrates that paired related homeobox protein 1 (Prrx1) is involved in PDGF-dependent hepatic stellate cell (HSCs) migration via modulation of the expression of metalloproteinases MMP2 and MMP9. PDGF elevated the level of Prrx1 through the activation of ERK/Sp1 and PI3K/Akt/Ets1 pathways. In vivo, an adenoviral-mediated Prrx1 shRNA administration attenuated liver fibrosis in thioacetamide-induced fibrotic models. These studies reveal a role of Prrx1 as a modulator of PDGF-dependent signaling in HSCs, and inhibiting its expression may offer a therapeutic approach for hepatic fibrosis.

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Year:  2017        PMID： 28737764     DOI： 10.1038/labinvest.2017.65

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


  40 in total

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Authors:  Takashi Naito; Yoko Tanihata; Hideki Nishimura; Toshihisa Tanaka; Chieko Higuchi; Takashi Taguchi; Tsutomu Sanaka
Journal:  Nephrol Dial Transplant       Date:  2005-07-26       Impact factor: 5.992

2.  The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis.

Authors:  Maximilian Reichert; Shigetsugu Takano; Johannes von Burstin; Sang-Bae Kim; Ju-Seog Lee; Kaori Ihida-Stansbury; Christopher Hahn; Steffen Heeg; Günter Schneider; Andrew D Rhim; Ben Z Stanger; Anil K Rustgi
Journal:  Genes Dev       Date:  2013-01-25       Impact factor: 11.361

3.  Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice.

Authors:  Shuhei Yoshida; Naoki Ikenaga; Susan B Liu; Zhen-Wei Peng; Jeanhee Chung; Deanna Y Sverdlov; Makoto Miyamoto; Yong Ook Kim; Shinji Ogawa; Robert H Arch; Detlef Schuppan; Yury Popov
Journal:  Gastroenterology       Date:  2014-08-28       Impact factor: 22.682

4.  Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.

Authors:  Jianguo Lin; Anping Chen
Journal:  Lab Invest       Date:  2008-03-10       Impact factor: 5.662

5.  Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor.

Authors:  D A Grueneberg; S Natesan; C Alexandre; M Z Gilman
Journal:  Science       Date:  1992-08-21       Impact factor: 47.728

6.  Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

Authors:  P Soriano
Journal:  Genes Dev       Date:  1994-08-15       Impact factor: 11.361

7.  β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis.

Authors:  Peri Kocabayoglu; Abigale Lade; Youngmin A Lee; Ana-Cristina Dragomir; Xiaochen Sun; Maria Isabel Fiel; Swan Thung; Costica Aloman; Philippe Soriano; Yujin Hoshida; Scott L Friedman
Journal:  J Hepatol       Date:  2015-02-09       Impact factor: 25.083

8.  FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration.

Authors:  David M McKean; Lila Sisbarro; Dusko Ilic; Nihal Kaplan-Alburquerque; Raphael Nemenoff; Mary Weiser-Evans; Michael J Kern; Peter Lloyd Jones
Journal:  J Cell Biol       Date:  2003-04-28       Impact factor: 10.539

9.  miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin β1 and matrix metalloproteinase2 (MMP2).

Authors:  Heyong Wang; Yingchao Zhu; Mingchuan Zhao; Chunlian Wu; Peng Zhang; Liang Tang; Huijun Zhang; Xiaofeng Chen; Yaoqin Yang; Gentao Liu
Journal:  PLoS One       Date:  2013-08-06       Impact factor: 3.240

10.  Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.

Authors:  Brian J Hayes; Kimberly J Riehle; Masami Shimizu-Albergine; Renay L Bauer; Kelly L Hudkins; Fredrik Johansson; Matthew M Yeh; William M Mahoney; Raymond S Yeung; Jean S Campbell
Journal:  PLoS One       Date:  2014-03-25       Impact factor: 3.240
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  9 in total

1.  A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy.

Authors:  Zhao Li; Tianshan She; Hao Yang; Tao Su; Qiuxiao Shi; Ze Tao; Yanru Feng; Fen Yang; Jingqiu Cheng; Xiaofeng Lu
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.819

2.  Transcriptional regulation of Hepatic Stellate Cell activation in NASH.

Authors:  Ann-Britt Marcher; Sofie M Bendixen; Mike K Terkelsen; Sonja S Hohmann; Maria H Hansen; Bjørk D Larsen; Susanne Mandrup; Henrik Dimke; Sönke Detlefsen; Kim Ravnskjaer
Journal:  Sci Rep       Date:  2019-02-20       Impact factor: 4.379

3.  Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.

Authors:  Andrea Villar-Lorenzo; Patricia Rada; Esther Rey; Patricia Marañón; Ana I Arroba; Beatriz Santamaría; Jorge Sáiz; Francisco J Rupérez; Coral Barbas; Carmelo García-Monzón; Ángela M Valverde; Águeda González-Rodríguez
Journal:  Dis Model Mech       Date:  2019-07-16       Impact factor: 5.758

Review 4.  Epithelial-mesenchymal transition and its transcription factors.

Authors:  Pallabi Debnath; Rohit Singh Huirem; Paloma Dutta; Santanu Palchaudhuri
Journal:  Biosci Rep       Date:  2022-01-28       Impact factor: 3.840

5.  Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models.

Authors:  Benjamin Strobel; Holger Klein; Germán Leparc; Birgit E Stierstorfer; Florian Gantner; Sebastian Kreuz
Journal:  Sci Rep       Date:  2022-07-16       Impact factor: 4.996

6.  The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis.

Authors:  Dinh Vinh Do; So Young Park; Giang Thi Nguyen; Dae Hee Choi; Eun-Hee Cho
Journal:  Endocrinol Metab (Seoul)       Date:  2022-07-22

7.  COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1.

Authors:  Simon N Dankel; Elise Grytten; Jan-Inge Bjune; Hans Jørgen Nielsen; Arne Dietrich; Matthias Blüher; Jørn V Sagen; Gunnar Mellgren
Journal:  Sci Rep       Date:  2020-11-19       Impact factor: 4.379

Review 8.  Metabolic Reprogramming of Liver Fibrosis.

Authors:  M Eugenia Delgado; Beatriz I Cárdenas; Núria Farran; Mercedes Fernandez
Journal:  Cells       Date:  2021-12-20       Impact factor: 6.600

9.  Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis.

Authors:  Zhong-Yi Wang; Adrian Keogh; Annick Waldt; Rachel Cuttat; Marilisa Neri; Shanshan Zhu; Sven Schuierer; Alexandra Ruchti; Christophe Crochemore; Judith Knehr; Julie Bastien; Iwona Ksiazek; Daniel Sánchez-Taltavull; Hui Ge; Jing Wu; Guglielmo Roma; Stephen B Helliwell; Deborah Stroka; Florian Nigsch
Journal:  Sci Rep       Date:  2021-09-29       Impact factor: 4.379
  9 in total

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